Results 91 to 100 of about 7,724 (303)

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin   +11 more
wiley   +1 more source

Does the use theory of meaning entail legal realism?

open access: yesRevista Direito Mackenzie, 2016
It is argued that there is a close connection between Wittgenstein’s UseTheory of Meaning (UT) and Legal Realism (LR). Therefore, if you accept one, you can hardly avoid accepting the other, on pain of inconsistency.
Seppo Sajama
doaj   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi   +12 more
wiley   +1 more source

Jurisprudential Responses to Legal Realism

open access: yes, 1988
The intellectual movement we call legal realism is today, I think, most often thought of as having an exclusively negative or critical character. But while this movement historically has had a strongly negative component, it has also had a positive or ...
Kronman, Anthony Townsend   +1 more
core   +1 more source

Concept of Russian Legal Realism in the Postclassical Paradigm

open access: yesТеоретическая и прикладная юриспруденция
Introduction. Postclassical jurisprudence is characterized by the integration of an analytical and empirical approach to researches, which has been notably evident in recent decades.
E. N. Tonkov
doaj  

Book Review: Legal Realism at Yale, 1927-1960

open access: yes, 1988
Laura Kalman\u27s monograph, originally a dissertation, is nevertheless a fresh and rather engaging study of a finished chapter in intellectual history—the legal realist movement.
Brown, Ralph S., Jr.
core  

Femtosecond‐Laser‐Induced Physical Unclonable Random Maze Structure for Storage‐Free Encryption

open access: yesAdvanced Science, EarlyView.
Femtosecond‐laser‐induced gold random maze structures serve as multimodal physical unclonable functions for storage‐free encryption. Their stochastic optical, electrical, and Raman responses are generated by plasmon‐assisted Marangoni formation and converted into AES‐compatible keys without permanent secret‐key storage, offering a portable route toward
Shiru Jiang   +6 more
wiley   +1 more source

Questions à James Q. Whitman

open access: yesCahiers Jean Moulin, 2018
À l’occasion de la parution de son dernier ouvrage (Whitman, 2017), il a paru utile de revenir sur les travaux de James Q. Whitman, professeur d’histoire du droit et de droit comparé à l’Université de Yale.
James Q. Whitman   +2 more
doaj   +1 more source

How Video‐Based Information Affects Farmers' Willingness to Pay for Drone Services

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT Professional service for digital technology like agricultural drones lowers transaction costs and scope thresholds for smallholders. Meanwhile, perceptual adoption barriers remain underexplored. We conduct a two‐stage choice experiment with a randomized video‐based information treatment among 384 Chinese crop farmers to measure its effect on ...
Hua Zhang   +4 more
wiley   +1 more source

Feminist Legal Realism

open access: yes, 2012
This Article begins to rethink current conceptions of two of the most significant legal movements in this country1—Legal Realism and Feminist Jurisprudence. The story of Legal Realism has been retold for decades.
Quinn, Mae C.
core   +1 more source

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