Results 101 to 110 of about 5,052,444 (201)

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source

Erratum to: On the issue of defining the essence of the object of the intangible cultural heritage: historical retrospective and significance for the development of modern society

SHS Web of Conferences, 2018
Doguzhaeva Muminat, Dorokhov Nikolai, Kochepasova Tatiana, Nazarenko Natalia, Simaeva Evgeniya   +4 more
doaj   +1 more source

Implementing the Nature Restoration Regulation Report. Part I - Legal Context

This report provides a comprehensive analysis of the European Union’s Nature Restoration Regulation (EU) 2024/1991 (NRR), focusing particularly on legal issues raised by the implementation of this innovative, ambitious legal regime.
morgan eleanor harris, katia laffusa, stefano porfido   +2 more
core  

Legal Momentum : the Women\u27s Legal Defense and Education Fund

, 2021
Legal Momentum, a 501(c)3 nonprofit, founded in 1970 is the oldest legal advocacy group for women in the United States, formerly known as NOW Legal Defense and Education Fund.
Legal Momentum (Organization)
core  

Symptom‐Driven Prediction of Chronic Multimorbidity with a Macro–Micro Heterogeneous Graph Neural Network

Advanced Science, EarlyView.
Clinical symptoms offer a window into multimorbidity. A macro‐micro heterogeneous graph neural network integrates clinical records with biomedical knowledge to improve patient‐level symptom‐disease association learning and visit‐level multimorbidity completion.
Yiheng Ye, Miaoru Han, Siqiao Tang, Zongxiang Zhang, Haichen Shen, Bingzhen Sun, Yan Zhang, Xiaodong Chu, Lijuan Deng, Chaoyang Zheng, Qingchun Huang, Kun Bao, Ronghua Zhang, Yong Wang, Fengwei Zhang, Xiaoli Chu   +15 more
wiley   +1 more source

Conducting Business Activities in Special Conditions: Problems of Legal Regulation

peer reviewedThis article explores the problems of conducting business in conditions that differ from generally accepted standards and norms. Special conditions may include situations such as economic crises, natural disasters, martial law, or other ...
Stanislav, Sieriebriak, Sergii, Solodchenko, Maksym, Bespalov, KRAVTSOV, Serhii   +3 more
core   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Ohio DDP and funding for individual options waiver

, 2006
Title from PDF cover (viewed on Jan. 22, 2007).; "September 2006"--P. 3 of cover.; Harvested from the web on 1/22/07Frequently asked questions about the Individual Options Waiver of the Ohio Developmental Disabilities Profile (ODDP) answered by the Ohio ...
Ohio Legal Rights Service.
core  

What a Hybrid Legal-Technical Analysis Teaches Us About Privacy Regulation: The Case of Singling Out

, 2020
This article advocates a hybrid legal-technical approach to the evaluation of technical measures designed to render information anonymous in order to bring it outside the scope of data protection regulation.
Cohen, Aloni, Nissim, Kobbi, Wood, Alexandra, Altman, Micah   +3 more
core