Results 91 to 100 of about 2,561,148 (312)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

The Adequacy of Doctor Patient the Relationship to the Requirements of Validity of the legal Transaction: the Doctor Patient Relationship as legal Phenomenon

open access: yesScientia Iuris, 2015
This work is interdisciplinary and aims to examine the adequacy of the patient-physician relationship to the requirements of validity of legal business.
Silvio Romero Beltrão
doaj   +1 more source

Decentralization and corruption - evidence across countries [PDF]

open access: yes
The relationship between decentralization of government activities and the extent of rent extraction by private parties is an important element in the recent debate on institutional design.
Fisman, Raymond, Gatti, Roberta
core  

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li   +22 more
wiley   +1 more source

THE USE OF EQUITABLE RIGHT AS ONE OF THE FORMS OF ITS REALIZATION

open access: yesRussian Journal of Economics and Law, 2008
The article views the notions of equitable right and authority, and gives their juridical characteristics.
T. Yakovleva
doaj  

Size-related Hooking Mortality of Incidentally Caught Chinook Salmon, Oncorhynchus tshawytscha [PDF]

open access: yes, 1989
Mortality associated with the incidental catch and release by commercial trollers of two size classes of chinook salmon, Oncorhynchus tshawytscha, was assessed. Observed cumulative mortality 4-6 days after hooking was 18.3 percent for sublegal-sizefish «
Celewycz, Adrian   +3 more
core  

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao   +11 more
wiley   +1 more source

Specificity of delictual legal relationship in case of poor-quality prenatal diagnostics services (civil, political, and legal aspects)

open access: yesУченые записки Казанского университета: Серия Гуманитарные науки, 2018
This paper addresses the issues of the delictual (tort) liability for the poor-quality provision of prenatal diagnostics. The relevance of the research can be explained as follows: the issue of recovering the expenses for lifelong treatment and caring ...
K.V. Egorov, E.S. Egorova
doaj  

Capital Regulation and Credit Risk Taking : Empirical Evidence from Banks in Emerging Market Economies [PDF]

open access: yes
The primary purpose of this article is to investigate the relationship between bank capital and credit risk taking in emerging market economies. We also investigate the influence of several regulatory, institutional and legal features on the relationship
Christophe Godlewski
core  

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

open access: yesAdvanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy