Results 101 to 110 of about 468,826 (310)

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

open access: yesAdvanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi   +8 more
wiley   +1 more source

Right to legal aid [PDF]

open access: yes, 2015
This thesis deals with an issue of a right to legal aid. The aim of the thesis is to introduce how the right to legal aid as a one of the basic human rights falling within so called right to a fair trial is implemented in the Czech Republic.
Šustová, Jana
core  

Legal preemption right

open access: yes, 2022
Tezimizde Türk Medeni Kanunu'nda düzenlenen yasal önalım hakkını inceledik. Tezimizi giriş, üç bölüm ve sonuç kısımları oluşturmaktadır. Giriş bölümünde konunun takdimi ve sınırlandırması yapıldıktan sonra yasal önalım hakkının ekonomik, sosyal ve hukuki
Satılmış,İsmail
core  

Subjective Right in the Post-Classical Legal Science

open access: yesТеоретическая и прикладная юриспруденция, 2019
The writer formulates the content and characteristics of a subjective right in post-classical legal science context. Postclassical jurisprudence develop rethinking the objectivity of law. Therefore, objective and subjective law complement each other. The
I. L. Chestnov
doaj  

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

open access: yesAdvanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng   +15 more
wiley   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun   +27 more
wiley   +1 more source

Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education

open access: yesAdvanced Science, EarlyView.
We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua   +6 more
wiley   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

open access: yesAdvanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing   +10 more
wiley   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

open access: yesAdvanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao   +25 more
wiley   +1 more source

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