Results 121 to 130 of about 570,634 (313)
A Prospectus for Canadian Legal History [PDF]
, 1973 The study of legal history can be a useful and scholarly undertaking. An understanding of the uses and limits of law is useful, if not necessary, for any civilized community, and a study of legal history is one way, although not the exclusive way, of ...
Risk, R. C. B.
core +1 more source
Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome
Advanced Science, EarlyView.We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu +19 more
wiley +1 more source
Forensic SciencesBackground: Among the deaths recorded during the COVID-19 pandemic, some were caused by clinical manifestations of venous thromboembolic disease, mainly pulmonary embolism.
Giuseppe Basile +4 more
doaj +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Controversial Defenses to Legal Malpractice Claims: Are Attorney-Experts Being Asked to Be Advocates? [PDF]
, 2014 Attorney-experts in legal malpractice litigation are like many other experts. Although easily distinguishable from experts offering science-based testimony, attorney expertise is similar to that of witnesses offering experience-based testimony, and ...
David S. Caudill, Caudill, David S.
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Using Data Analytics to Predict an Individual Lawyer\u27s Legal Malpractice Risk Profile: Becoming an LPL Precog [PDF]
, 2020 The power of data analytics is revolutionizing the way that business is conducted in nearly every industry. The medical industry, the consumer/retail space, and the banking and financial industries are taking their business operations to the next level ...
Rapoport, Nancy B. +1 more
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Advanced Science, EarlyView.The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
wiley +1 more source
The Risk at the Heart of Criminal Policy: the Revival of a Realist Epistemology? [PDF]
, 2012 While it is central in the social science’s analysis on the concept of risk, the epistemological debate on the different approaches of risk has been largely absent from the legal scholar addressing the legal regulation of risk.
Pieret, Julien
core
Advanced Science, EarlyView.ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng +15 more
wiley +1 more source
Advanced Science, EarlyView.We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua +6 more
wiley +1 more source