Results 111 to 120 of about 408,790 (313)

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Mortality due to H1N1 Influenza in Cases Registered at the Autopsy Halls of Kahrizak, Tehran

International Journal of Medical Toxicology and Forensic Medicine, 2023
Mehdi Forouzesh, Ramin Talaie, Nahid Dadashzadehasl, Seyed Shahram Mousavi, Abdolrazagh Barzegar, Seyed Amirhosein Mahdavi, Masoud Ghadipasha, Roya Kordrostami, Rohollah Valizadeh   +8 more
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

From Illegal to Legal: Estimating Previous Illegal Experience among New Legal Immigrants to the United States [PDF]

This paper develops a framework for estimating previous illegal experience among annual cohorts of new legal immigrants to the United States – using public-use administrative microdata alone, survey data alone, and the two jointly – and provides ...
Rosenzweig, Mark R., Massey, Douglas S., Jasso, Guillermina, Smith, James P.   +3 more
core  

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Labour rights of the rare diseases population ‒ breaking the glass ceiling

Stanovništvo, 2020
This paper aims to introduce a legal framework for exercising one of the most basic socio-economic rights of people with rare diseases: the right to decent work.
Sanja Stojković Zlatanović, Marta Sjeničić, Ranko Sovilj   +2 more
doaj  

Moral Position In Legal Science: An Analysis of The Dynamics of Legal Science Development

KRTHA BHAYANGKARA
The emphasis of moral principle lies in the beneficial purpose of law subjected to lengthy problems regarding the placement. Different analyses have been carried out relating to the effects of natural law and positivism in legal science. Therefore, this study aims to achieve an understanding of the position of moral principle in legal science in the ...
openaire   +1 more source

Progressive Legal Thought

, 2015
A widely accepted model of American legal history is that classical legal thought, which dominated much of the nineteenth century, was displaced by progressive legal thought, which survived through the New Deal and in some form to this day.
Hovenkamp, Herbert, Hovenkamp, Herbert J.   +1 more
core  

Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education

Advanced Science, EarlyView.
We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua, Anira Escrichs, Yonatan Sanz Perl, Morten L. Kringelbach, Adele Diamond, Solange Denervaud, Gustavo Deco   +6 more
wiley   +1 more source