Results 81 to 90 of about 2,684,738 (314)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao   +7 more
wiley   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon   +11 more
wiley   +1 more source

Temporal Aspects of Smart Contracts for Financial Derivatives

open access: yes, 2018
Implementing smart contracts to automate the performance of high-value over-the-counter (OTC) financial derivatives is a formidable challenge. Due to the regulatory framework and the scale of financial risk if a contract were to go wrong, the performance
C Clack, D Magazzeni, N Rescher, RM Lee
core   +1 more source

Two internal critiques of political constitutionalism [PDF]

open access: yes, 2012
The antagonism between legal and political constitutionalism has almost monopolized the discussion on constitutional theory during the last years.
Goldoni, M.
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

Legitimacy as the sign of the right

open access: yesТеоретическая и прикладная юриспруденция, 2019
Legitimacy constructed and constituts society, including the right to. Here possible conclusion, that legitimacy is the feature of the law. However not all agree with this point.
I. L. Chestnov
doaj  

Law as an innovative system: theoretical approach

open access: yesПравоприменение
The subject of the study is the extrapolation of the main provisions of innovation to the legal form of social existence. The purpose of the article is to disclose and systematize the key elements of understanding law as an innovative system.Methodology.
M. V. Shugurov, A. A. Vasiliev
doaj   +1 more source

Re-Imagining Justice [PDF]

open access: yes, 2003
What do we mean by legal justice, as opposed to distributive, or social, or political justice; what is the justice, that is, we hope law promotes? What is the justice that lawyers and judges, peculiarly, are professionally committed to pursue?
West, Robin
core   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto   +12 more
wiley   +1 more source

Animals, Slaves, and Corporations: Analyzing Legal Thinghood [PDF]

open access: yes, 2017
The Article analyzes the notion of legal “thinghood” in the context of the person–thing bifurcation. In legal scholarship, there are numerous assumptions pertaining to this definition that are often not spelled out.
Kurki, Visa A. J.
core  

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