Results 131 to 140 of about 4,115 (300)

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

open access: yesAdvanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo   +14 more
wiley   +1 more source

Selective Legality and The Use of Force: Reassessing U.S. Military Interventions in Sovereign States Under International Law

open access: yesBTTN Journal
This study reviews the military interventions of the United States through the conceptual lens of strategic legalism, which is perceived to imply the instrumental and selective application of international legal norms to aid, not restrict, the use of ...
Akeem Aderayo SARAKI
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

open access: yesAdvanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang   +12 more
wiley   +1 more source

Rule of Law Measures and Executive Legalism

open access: yesAJIL Unbound
The rule of law is a loaded concept. It is frequently invoked as a social ideal, but no one appears to know exactly what it means. The thinnest of definitions views the rule of law as merely a set of process criteria that an enactment must meet to ...
Elena Chachko
doaj   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

open access: yesAdvanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing   +10 more
wiley   +1 more source

Heyday of autocratic legalism in Slovakia

open access: yes
On 8 February 2024, Slovakia’s parliament approved an amendment to its criminal code and associated legislation that, if it comes into effect, will significantly reduce the prescription periods for various crimes including rape, the penalties for others,
Steuer, Max
core  

Adversarial legalism and American government

open access: yes
Compared to other economically advanced democracies, the United States is uniquely prone to adversarial, legalistic modes of policy formulation and implementation, shaped by the prospect of judicial review.
Robert A. Kagan
core   +1 more source

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