Results 41 to 50 of about 1,047,959 (349)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Ritual, Legend, and Metaphor: Narratives of the Willow in Yuan Zaju

Religions, 2022
Narratives of willow trees in Yuan zaju 雜劇, or variety play, largely come in three types, namely, the ritual performance of shooting willows; the deliverance of willow spirits by Lü Dongbin, one of the Eight Immortals of Daoism; and the use of the word ...
Qian Wang, Qiong Yang
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Wayland: smith of the gods [PDF]

, 2012
This paper considers the origins of the legend of Wayland, the Anglo-Saxon mythological smith. The origins of the Wayland legend come from Scandinavia but have roots in classic literature.
Mackley, J S
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mythic gaps

Nordlit: Tidsskrift i litteratur og kultur, 2014
Different kinds of omissions sometimes occur, or are perceived to occur, in traditional narratives and in tradition-inspired literature. A familiar instance is when a narrator realizes that he or she does not fully remember the story that he or she has ...
William Hansen
doaj   +1 more source

John M. Brumbaugh: A Celebration, A Tribute, A Farewell [PDF]

, 2001
A Tribute to a Legend: With Professor John Brumbaugh\u27s passing in early August, the School of Law marks the end of an era.
Leary, Betty Lynne
core   +1 more source

Low Background Materials and Fabrication Techniques for Cables and Connectors in the Majorana Demonstrator

, 2017
The MAJORANA Collaboration is searching for the neutrinoless double-beta decay of the nucleus Ge-76. The MAJORANA DEMONSTRATOR is an array of germanium detectors deployed with the aim of implementing background reduction techniques suitable for a tonne ...
Abgrall, N., Alvis, S. I., Arnquist, I. J., Avignone III, F. T., Barabash, A. S., Barton, C. J., Bertrand, F. E., Bode, T., Bradley, A. W., Brudanin, V., Busch, M., Buuck, M., Caldwell, T. S., Chan, Y-D., Christofferson, C. D., Chu, P. -H., Cuesta, C., Detwiler, J. A., Dunagan, C., Efremenko, Yu., Ejiri, H., Elliott, S. R., Gilliss, T., Giovanetti, G. K., Green, M. P., Gruszko, J., Guinn, I. S., Guiseppe, V. E., Haufe, C. R., Hehn, L., Henning, R., Hoppe, E. W., Howe, M. A., Keeter, K. J., Kidd, M. F., Konovalov, S. I., Kouzes, R. T., Lopez, A. M., Martin, R. D., Massarczyk, R., Meijer, S. J., Mertens, S., Myslik, J., O'Shaughnessy, C., Othman, G., Poon, A. W. P., Radford, D. C., Rager, J., Reine, A. L., Rielage, K., Robertson, R. G. H., Rouf, N. W., Shanks, B., Shirchenko, M., Suriano, A. M., Tedeschi, D., Trimble, J. E., Varner, R. L., Vasilyev, S., Vetter, K., Vorren, K., White, B. R., Wilkerson, J. F., Wiseman, C., Xu, W., Yakushev, E., Yu, C. -H., Yumatov, V., Zhitnikov, I., Zhu, B. X.   +69 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Bailar con el diablo: metamorfosis de una leyenda oral, del Abruzzo italiano a la literatura de cordel de Brasil

Boletín de Literatura Oral, 2019
This article presents different oral versions, for the most part unpublished, on the Dancing With the Devil legend. The author tries to outline, through a comparative analysis, the sequences and motifs found in this type of legend. The topic variants and
Cruz Carrascosa
doaj