Results 211 to 220 of about 503,738 (282)

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

open access: yesAdvanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency   +19 more
wiley   +1 more source

Capture and Culture of Circulating Tumor Cells Using a Biodegradable 3D Scaffold for Patient‐Derived Xenograft Construction

open access: yesAdvanced Science, EarlyView.
A self‐supporting, biocompatible, and biodegradable 3D cellulose scaffold has been developed for efficient isolation and in situ expansion of circulating tumor cells (CTCs) from patient blood. Subsequently, the 3D cellulose scaffold with cultured CTCs is directly implanted into immunodeficient mice for constructing patient CTC‐derived xenograft (CDX ...
Yi‐Ke Wang   +9 more
wiley   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

open access: yesAdvanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li   +12 more
wiley   +1 more source

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