Results 101 to 110 of about 104,885 (314)

Recessive Loss of PI4K2A Function Causes a Developmental and Epileptic Dyskinetic Encephalopathy with Prominent Orolingual Dyskinesia

Movement Disorders, EarlyView.
Abstract Background Biallelic loss‐of‐function variants in PI4K2A have been associated with a neurodevelopmental disorder characterized by seizures and movement disorders, including orofacial dyskinesia. However, only 4 cases have been reported. Orolingual dyskinesia—defined as involuntary movements of the mouth and tongue—is observed in various ...
Reza Maroofian, Juan Darío Ortigoza‐Escobar, Pooja Rohilla, Javeria Raza Alvi, Aziza M. Mushiba, Naif A.M. Almontashiri, Stephanie Efthymiou, Tipu Sultan, Tamas Balla, Henry Houlden   +9 more
wiley   +1 more source

Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes. [PDF]

, 1987
Legionella pneumophila, the causative agent of Legionnaires' disease, is a Gram-negative bacterium and a facultative intracellular parasite that multiplies in human monocytes and alveolar macrophages. In this paper, mutants of L.
Horwitz, MA
core  

Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages [PDF]

, 2018
Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole ...
Clemente, Tatiana M., Gilk, Stacey D., Justis, Anna V., Mulye, Minal, Nallandhighal, Srinivas, Tran, Tuan M.   +5 more
core   +1 more source

Case Report: Community-Acquired Legionella gormanii Pneumonia in an Immunocompetent Patient Detected by Metagenomic Next-Generation Sequencing

Frontiers in Medicine, 2022
BackgroundLegionella spp. has been well-recognized as an important cause of community-acquired pneumonia. Current community-acquired pneumonia guidelines recommended covering the treatment of Legionella because of the high mortality associated with ...
Cheng Lei, Cheng Lei, Cheng Lei, Xianglin Zhou, Xianglin Zhou, Xianglin Zhou, Shuizi Ding, Shuizi Ding, Shuizi Ding, Yingjie Xu, Yingjie Xu, Yingjie Xu, Binyi Yang, Binyi Yang, Binyi Yang, Wei Guo, Wei Guo, Wei Guo, Min Song, Min Song, Min Song, Min Yang, Min Yang, Min Yang, Yunan Jia, Yunan Jia, Yunan Jia, Hong Luo, Hong Luo, Hong Luo   +29 more
doaj   +1 more source

Legionella drozanskii sp. nov., Legionella rowbothamii sp. nov. and Legionella fallonii sp. nov.: three unusual new Legionella species. [PDF]

International Journal of Systematic and Evolutionary Microbiology, 2001
Seven strains of Legionella-like amoebal pathogens (LLAPs) were characterized on the basis of their cultural and staining characteristics, biochemical reactions, serology, cellular fatty acids (CFAs), isoprenoid quinone composition, total DNA relatedness, analysis of 16S rRNA and macrophage infectivity potentiator (mip) gene sequence analyses.
Adeleke, A A, Fields, B S, Benson, R F, Daneshvar, M I, Pruckler, J M, Ratcliff, R M, Harrison, T G, Weyant, R S, Birtles, R J, Raoult, D, Halablab, M A   +10 more
openaire   +3 more sources

Diversity and assembly of the microbiome of a leguminous plant along an urbanization gradient

Oikos, EarlyView.
Interactions between plants and bacterial communities are essential for host physiology and broader ecosystem functioning, but plant–microbiome interactions can be disrupted by environmental change like urbanization. Here, we evaluated how urbanization affected the diversity and assembly of soil and white clover Trifolium repens microbiome communities.
David Murray‐Stoker, Laura Rossi, Marc T. J. Johnson   +2 more
wiley   +1 more source

Predictable Modulation of a Spontaneous Post‐translational Modification in Living Cells

Angewandte Chemie, Volume 137, Issue 39, September 22, 2025.
A new tool is reported for studying methylglyoxal (MGO)‐derived protein glycation by incorporating single amino acid mutations that predictably modulate glycation levels. Mass spectrometry of intact proteins and proteolytic digests reveal Tyr (or Glu) substitutions result in an increase (or decrease) in site‐specific glycation, enabling precise control
Meghan S. Martin, Nomindari Bayaraa, Brittany T. Fox, Yu‐Shan Lin, Rebecca A. Scheck   +4 more
wiley   +2 more sources

The impact of co-infection of influenza A virus on the severity of Middle East Respiratory Syndrome Coronavirus [PDF]

, 2017
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Alfaraj, Sarah H., Altwaijri, Talal A., Alzahrani, Nojoom A., Memish, Ziad A.   +4 more
core   +1 more source

Symbiont-Mediated Defense against Legionella pneumophila in Amoebae

mBio, 2019
Bacterial pathogens are generally investigated in the context of disease. To prevent outbreaks, it is essential to understand their lifestyle and interactions with other microbes in their natural environment.
L. König, C. Wentrup, Frederik Schulz, Florian Wascher, Sarah Escola, M. Swanson, C. Buchrieser, M. Horn   +7 more
semanticscholar   +1 more source

Glycoproteomics and Its Role in Understanding Bacterial O‐Linked Glycosylation

PROTEOMICS, EarlyView.
ABSTRACT Protein glycosylation is now recognized as a ubiquitous process observed in all domains of life. Within bacterial species, carbohydrates can be attached to multiple residues with glycosylation of serine, threonine, or tyrosine residues via their hydroxyl side chains referred to as O‐linked glycosylation.
Kristian I. Karlic, Hamza Tahir, Nichollas E. Scott   +2 more
wiley   +1 more source