Guinea pigs sublethally infected with aerosolized Legionella pneumophila develop humoral and cell-mediated immune responses and are protected against lethal aerosol challenge. A model for studying host defense against lung infections caused by intracellular pathogens. [PDF]
, 1987 We have employed the guinea pig model of L. pneumophila infection, which mimics Legionnaires' disease in humans both clinically and pathologically, to study humoral and cell-mediated immune responses to L.
Breiman, RF, Horwitz, MA
core
Revista de Salud Ambiental, 2002 Se exponen las medidas de intervención adoptadas para el estudio y control del brote. Se encontraron 126 instalaciones con riesgo (45 de ellas de alto): 70 torres de refrigeración y similares, 35 fuentes ornamentales, 1 obra con movimiento de tierra y 20
F. Sintas Lozano +5 more
doaj
Factors Mediating Environmental Biofilm Formation by Legionella pneumophila
Frontiers in Cellular and Infection Microbiology, 2018 Legionella pneumophila (L. pneumophila) is an opportunistic waterborne pathogen and the causative agent for Legionnaires' disease, which is transmitted to humans via inhalation of contaminated water droplets.
Arwa Abu Khweek, A. Amer
semanticscholar +1 more source
Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection
Frontiers in Cellular and Infection Microbiology, 2018 Environmental bacteria of the genus Legionella naturally parasitize free-living amoebae. Upon inhalation of bacteria-laden aerosols, the opportunistic pathogens grow intracellularly in alveolar macrophages and can cause a life-threatening pneumonia ...
A. L. Swart +4 more
semanticscholar +1 more source
Small, EarlyView.Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source
Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity [PDF]
, 2020 Type III secretion systems are used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, into the cytosol of host cells. These virulence factors interfere with a diverse array of host signal transduction pathways and cellular
Araujo Garrido, Juan Luis +2 more
core +1 more source
Cas9 beyond CRISPR – SUMOylation, effector‐like potential and pathogenic adaptation
The FEBS Journal, EarlyView.This Viewpoint explores the possibility that Cas9, beyond its canonical role in CRISPR immunity, may act as a host‐modulating effector during infection by Cas9‐encoding bacteria. Such a nucleomodulin‐like function could be influenced by eukaryotic post‐translational modifications, particularly SUMOylation, with potential implications for host–pathogen ...
Umut Sahin
wiley +1 more source
Transposon mutagenesis in a hyper-invasive clinical isolate of Campylobacter jejuni reveals a number of genes with potential roles in invasion [PDF]
, 2010 Transposon mutagenesis has been applied to a hyper-invasive clinical isolate of Campylobacter jejuni, 01/51. A random transposon mutant library was screened in an in vitro assay of invasion and 26 mutants with a significant reduction in invasion were ...
Bagnall, MC +5 more
core +1 more source
Modelo de control y vigilancia en sanidad ambiental basados en sistemas de autocontrol
Revista de Salud Ambiental, 2006 En el ámbito ambiental el control de los riesgos para la salud está experimentando cambios importantes en lo referente a su concepción y a la forma de gestión de los mismos desde lo servicios de salud pública. Tradicionalmente la Administración Sanitaria
Loreto Santa Marina Rodríguez +1 more
doaj +2 more sources
A Unique Cytoplasmic ATPase Complex Defines the Legionella pneumophila Type IV Secretion Channel
Nature Microbiology, 2018 Type IV secretion systems (T4SSs) are complex machines used by bacteria to deliver protein and DNA complexes into target host cells1–5. Conserved ATPases are essential for T4SS function, but how they coordinate their activities to promote substrate ...
D. Chetrit +4 more
semanticscholar +1 more source