Advanced Science, Volume 13, Issue 2, 9 January 2026.The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen +5 more
wiley +1 more source
Characterization of Francisella species isolated from the cooling water of an air conditioning system. [PDF]
, 2015 Strains of Francisella spp. were isolated from cooling water from an air conditioning system in Guangzhou, China. These strains are Gram negative, coccobacilli, non-motile, oxidase negative, catalase negative, esterase and lipid esterase positive.
Atwill, Edward +6 more
core +3 more sources
Legionella colonization and 3D spatial location within a Pseudomonas biofilm
Scientific ReportsBiofilms are known to be critical for Legionella settlement in engineered water systems and are often associated with Legionnaire’s Disease events. One of the key features of biofilms is their heterogeneous three-dimensional structure which supports the ...
Ana Rosa Silva +3 more
doaj +1 more source
Robert Koch, Creation, and the Specificity of Germs [PDF]
, 2010 Microbiology is dominated by evolution today. Just look at any text, journal article, or the topics presented at professional scientific meetings. Darwin is dominant. Microbiology is dominated by evolution today.
Gillen, Alan L. +2 more
core +1 more source
Polar delivery of Legionella type IV secretion system substrates is essential for virulence [PDF]
, 2017 A recurrent emerging theme is the targeting of proteins to subcellular microdomains within bacterial cells, particularly to the poles. In most cases, it has been assumed that this localization is critical to the protein’s function. Legionella pneumophila
Chang, Yi-Wei +4 more
core +1 more source
Molecular diversity and high virulence of Legionella pneumophila strains isolated from biofilms developed within a warm spring of a thermal spa. [PDF]
, 2013 International audienceABSTRACT: BACKGROUND: Several cases of legionellosis have been diagnosed in the same French thermal spa in 1986, 1994 and 1997. L.
Atlan, Danièle +6 more
core +4 more sources
Factors Influencing Legionella Contamination of Domestic Household Showers
Pathogens, 2019 Legionnaires’ disease is a potentially fatal pneumonia like infection caused by inhalation or aspiration of water particles contaminated with pathogenic Legionella spp.
Deanna Hayes-Phillips +3 more
doaj +1 more source
Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors. [PDF]
, 1987 We have examined receptors mediating phagocytosis of the intracellular bacterial pathogen, Legionella pneumophila. Three mAbs against the type 3 complement receptor (CR3), which recognizes C3bi, inhibit adherence of L.
Horwitz, MA, Payne, NR
core
Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins [PDF]
, 2010 Legionella pneumophila is a ubiquitous inhabitant of environmental water reservoirs. The bacteria infect a wide variety of protozoa and, after accidental inhalation, human alveolar macrophages, which can lead to severe pneumonia. The capability to thrive
Beatson, Scott A. +13 more
core +1 more source
PathogensLegionella is an underdiagnosed and underreported etiology of pneumonia. Legionella pneumophila serogroup 1 (LpSG1) is thought to be the most common pathogenic subgroup.
Ryan Ha +6 more
doaj +1 more source