Results 31 to 40 of about 10,256,157 (153)

Legionella and legionnaires' disease: An overview

Journal of Acute Disease, 2019
Legionellosis is the generic term used to describe infections caused by different varieties of Legionella spp., including Legionnaires’ disease (LD), a severe and potentially fatal form of pneumonia, and Pontiac fever, a self-limited flu-like illness ...
Dr. Nabi Jomehzadeh, M. Moosavian, M. Saki, Mohammad Rashno   +3 more
semanticscholar   +1 more source

Polyphosphates Attenuate Interleukin‐12 Production in Macrophages Infected With Legionella pneumophila

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Legionella pneumophila infection leads to the release of pathogen‐associated molecular patterns, which recruits the adaptor protein MYD88, initiating both activating (e.g., NF‐κB) and inhibitory (e.g., PI3K/AKT) signaling pathways that regulate IL‐12 gene expression.
Kara Vasilew, Archana Jayaraman, Johannes Platten, Shuang Xu, Sarah Josinsky, Julian Roewe, Maximilian Mimmler, Jonathan Kilroy, Fedoua Echahidi, Ziya Kaya, Dario S. Zamboni, Christoph Reinhardt, Markus Bosmann   +12 more
wiley   +1 more source

Legionnaires' disease [PDF]

Arthritis & Rheumatism, 1979
T W, Steele, D J, Merry, J L, Pitt
  +8 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, Volume 600, Issue 11, Page 1589-1604, June 2026.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The Contribution of Chemistry to the Detection and Enumeration of Legionella pneumophila in Environmental Water Samples: Experience With the MICA Method

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Legionella pneumophila is the principal species responsible for Legionnaires' disease, and measuring microbial load is fundamental to the analysis of environmental water samples. This study compared a new lipopolysaccharide bioprobe method (Microcolony Counter Analysis), which detects and counts L.
Savina Ditommaso, Jacopo Garlasco, Carla Streva, Gabriele Memoli, Carla M. Zotti, Fabrizio Bert, Monica Giacomuzzi   +6 more
wiley   +1 more source

Vital Signs: Health Care–Associated Legionnaires’ Disease Surveillance Data From 20 States and a Large Metropolitan Area—United States, 2015

American Journal of Transplantation, 2017
Legionnaires’ disease, a severe pneumonia, is typically acquired through inhalation of aerosolized water containing Legionella bacteria. Legionella can grow in the complex water systems of buildings, including health care facilities.
Elizabeth A. Soda, Albert E. Barskey, P. Shah, Stephanie J. Schrag, Cynthia G. Whitney, M. Arduino, Sujan C. Reddy, Jasen M. Kunz, Candis M. Hunter, Brian H Raphael, L. Cooley   +10 more
semanticscholar   +1 more source

Nodular Legionnaire disease [PDF]

American Journal of Roentgenology, 1981
Legionnaire disease is now recognized to be an acute bacterial pneumonitis caused by the fastidious, Gram-negative bacillus Legionella pneumophila. In a review of 35 cases, Kirby et al. [1 ] reported that all patients had pulmonary infiltrates nadiographically at some time in their course with pleural effusion in most cases.
J B, Carter, R K, Wolter, G, Angres, P, Saltzman   +3 more
openaire   +2 more sources

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans

PLoS Pathogens, 2018
The cyclic GMP-AMP synthase (cGAS)-STING pathway is central for innate immune sensing of various bacterial, viral and protozoal infections. Recent studies identified the common HAQ and R232H alleles of TMEM173/STING, but the functional consequences of ...
J. S. Ruiz-Moreno, L. Hamann, Javeed A. Shah, A. Verbon, F. Mockenhaupt, M. Puzianowska-Kuźnicka, Jana Naujoks, L. Sander, M. Witzenrath, J. Cambier, N. Suttorp, R. Schumann, Lei Jin, T. Hawn, B. Opitz   +14 more
semanticscholar   +1 more source

Hemophagocytic Lymphohistiocytosis Triggered by Legionella pneumophila and SARS‐CoV‐2 Infection in GATA2 Deficiency

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Germline GATA2 deficiency predisposes to bone marrow failure, myeloid neoplasia, and immune dysregulation. The syndrome is often complicated by infection with intracellular pathogens and viruses, autoimmunity, and inflammation. Hemophagocytic lymphohistiocytosis (HLH) is a rare occurrence that can present further management challenges.
Harry Wilson, Nuno Borges, Matthew Collin, Callum Wright   +3 more
wiley   +1 more source