Results 61 to 70 of about 2,240 (260)

Rumen Protozoa: The Animals within the Cow

open access: yesEDIS, 2017
As a cow ambles around and eats from the feed bunk, legions of other “animals” are feeding within the cow’s rumen. Billions of protozoa swim about in a single, 20-gallon rumen, colliding with one another while engulfing feed particles and bacteria ...
Timothy J. Hackmann
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

La “causa de Montevideo”. Inmigración, legionarismo y voluntariado militar en el Río de la Plata, 1848-1852

open access: yesNuevo mundo - Mundos Nuevos, 2012
Based on recent studies of international military volunteering networks in the nineteenth Century, this article discusses the enrollment projects carried out by the Montevidean diplomacy in Europe during the last stage of the "Guerra Grande" (1848-1852 ...
Mario Etchechury Barrera
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Mitologizacje, ceremonie, apoteozy: Piłsudski i Legiony w teatrze krakowskim

open access: yesPamiętnik Teatralny, 2018
Cracow theatre played a special part in the Polish ritual of passage from subjugation to independence in 1918 and soon became an object of intense mythologizing itself.
Diana Poskuta-Włodek
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

The last legions: The “barbarization” of military identity in the Late Roman West

open access: yesTabula, 2016
Traditional scholarship has argued that during the fourth and fifth centuries the waning Roman Empire came to rely to a large extent on recruits of foreign, barbarian origin for its defence.
Vedran Bileta
doaj   +1 more source

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