Results 131 to 140 of about 111,424 (313)

Ten‐Year Public Expenditure Savings Associated with TNF Inhibitor Biosimilars under Australia's Pharmaceutical Benefits Scheme

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Biologic therapies are a major and growing driver of pharmaceutical expenditure globally, with tumor necrosis factor (TNF) inhibitors among the most widely used and costly biologics. In Australia, these therapies are funded through the Pharmaceutical Benefits Scheme (PBS), where biosimilars offer lower cost alternatives; however, the long‐term public ...
Chin Hang Yiu   +4 more
wiley   +1 more source

Drug policy reform in South America: Towards a Multiaxial Model of Preventive Regulation

open access: yesRelaciones Internacionales, 2016
Since the creation of the Union of South American Nations (UNASUR) in 2008, its members evidence an endogenous contradiction in relation to the illegal drug issue.
Nicolás Matías COMINI
doaj  

The Impact of drugs on different minority groups: ethnicity and drug treatment.

open access: yes, 2010
This short report has been produced as part of a wider review seeking to pull together the available information on the impact of illicit drugs on a number of diverse minority groups: ethnic minority groups; lesbian, gay, bisexual and transgender people;

core  

Digital Transformation of Medicines Regulation in Africa—Perspectives from a Stakeholder Convening

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Regulatory authorities worldwide are developing strategies to integrate artificial intelligence (AI) into the lifecycle of health products, technologies, and medicines. While regulators share goals of improving efficiency, strengthening decision‐making, and protecting public health, their approaches differ according to institutional structures ...
Christelna Reyneke   +12 more
wiley   +1 more source

Prescription drug importation legislation-other states

open access: yes, 2005
Electronic data.; Title from title screen.; "October 20, 2005."; Outlines 2005 legislation passed in other states addressing prescription drug importation or reimportation.; Harvested from the web on 11/9 ...
Kasprak, John.
core  

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Plasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Nihan Izat   +6 more
wiley   +1 more source

Social Accounting for Work‐Related Injuries: Towards a Sustainable Management of Social Externalities

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The present study seeks to advance the understanding of the determinants of occupational injuries, thereby enhancing both academic knowledge and decision‐making in the management and implementation of occupational health and safety measures.
Rosa María Cañaveras Perea   +2 more
wiley   +1 more source

Drug House Legislation; March 9, 1994

open access: yes, 1994
Governor Thompson at the Silver Spring Neighborhood Center during the signing ceremony for the ""drug house"" legislation; City of Milwaukee; Milwaukee County; Wisconsin; March 9, 1994.
Boehm & Associates, Inc.
core  

Identification and Characterization of the Designer Opioid N‐Pyrrolidino Fluetonitazene in Nasal Spray

open access: yesDrug Testing and Analysis, EarlyView.
N‐Pyrrolidino fluetonitazene, a synthetic opioid, was identified and characterized in a nasal spray using GC‐MS, LC‐QTOF‐MS, NMR and FT‐IR. ABSTRACT Detection of drugs in non‐biological samples serves as a fundamental basis for identifying emerging trends in the field of new psychoactive substances and provides valuable information for optimizing ...
Fabian Picht   +4 more
wiley   +1 more source

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

open access: yesDrug Testing and Analysis, EarlyView.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand   +4 more
wiley   +1 more source

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