Results 111 to 120 of about 978,807 (286)

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

Lysyl Oxidase Reduces Neutrophil Extravasation in Response to P. aeruginosa in an Infection‐on‐a‐Chip Model

Advanced NanoBiomed Research, EarlyView.
Lysyl oxidase crosslinking of type I collagen decreases neutrophil extravasation through an endothelium during the initial response to P. aeruginosa. This decrease in extravasation is likely due to the increase in VE‐cadherin expression between endothelial cells seeded on LOX‐crosslinked collagen hydrogels.
Christopher J. Calo, Tanvi Patil, Josephine Fouts, Eric L. Ginter, Margaret Radke, Hannah K. Weppner, Justin M. Owens, Laurel E. Hind   +7 more
wiley   +1 more source

Ethnicity and the surgical management of early invasive breast cancer in over 164 000 women

BJS (British Journal of Surgery), EarlyView., 2020
This large national study examined in detail the patterns in surgical management of early breast cancer in women of different ethnicities. Allowing for different patterns of age and stage at presentation, the surgical management of early breast cancer was similar in all women, regardless of ethnicity. All treated the same Background Limited information
T. Gathani, K. Chiuri, J. Broggio, G. Reeves, I. Barnes   +4 more
wiley   +1 more source

Analysis and improving countermeasures of medical disputes from the perspective of legal changes

Journal of Otology
Under the background of medical disputes growing in number, scale and intensity, tracing back legal changes in medical field as a breakthrough point, this paper took a legal perspective to illustrate changes in medical dispute settlements from ...
Zhang Linlin, Zhang Shimeng
doaj   +1 more source

Modulating Taste Perception in Newly Weaned Piglets: The Role of Palatability Additives in Enhancing Feed Intake and Performance

Animal Research and One Health, EarlyView.
Palatability enhancers modulate taste and smell, increasing feed acceptance, reducing weaning stress, and improving piglet performance. ABSTRACT The continuous growth of global agribusiness stimulates the search for alternatives that can enhance the performance and quality of life of production animals.
Luana Specht, Gabriela Altenhofen, Daiane Carvalho, Michele Fangmeier   +3 more
wiley   +1 more source

Costs of treating type 2 diabetes mellitus and its complications

Biotechnology & Biotechnological Equipment
The major driver of the costs of treating patients with diabetes mellitus type 2 (DM2) is its complications, which in developing countries are a consequence of poor glycemic control due to the low availability of novel, innovative antidiabetic drugs.
Nemanja Petrović, Miloš Milosavljević, Refet Gojak, Miralem Đešević, Dragana Lakić, Ivana Stević, Slobodan Janković   +6 more
doaj   +1 more source

Multivariate Analysis of Hematological Stress Biomarkers and Welfare Domains in Organic and Intensive Pig Farming in Italy: A Pilot Study

Animal Research and One Health, EarlyView.
Intensive or organic farming systems may expose pigs to management or environmental challenges. Our preliminary results concluded that organic farming might enhance adaptive immune function, showing that improvements in welfare can translate into measurable immunological benefits, based on the correlation between welfare assessment and physiological ...
Dorotea Ippolito, Talal Hassan, Antonio Marco Maisano, Stefania Bergagna, Cecilia Guasco, Barbara Miniscalco, Martina Tarantola, Elena Colombino, Claudio Caruso, Ahsan Muhammad, Silvia Mioletti, Laura Tomassone, Massimiliano Tursi, Cristina Vercelli, Giovanni Loris Alborali, Maria Teresa Capucchio   +15 more
wiley   +1 more source

Children in need of medical innovation [PDF]

Children are therapeutic orphans and an underprivileged group in innovations derived from drug therapy. As the innovation process of pharmaceuticals is a long, risky and very costly business, economists typically emphasise lack of profit incentives and ...
Entorf, Horst, Fegert, Jörg, Kölch, Michael   +2 more
core  

People with Disabilities in Lao PDR Training for Employment and Income Generation: Key Issues and Potential Strategies [PDF]

, 1998
No136.pdf: 4010 downloads, before Oct.
Murray, Barbara
core   +1 more source

The United States Leads the Globe in Venture Capital Funding for Orthopaedic Surgery

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To characterize venture capital (VC) investments in orthopaedic surgery over the past 25 years to evaluate trends in global innovation. Methods All VC investments related to orthopaedic surgery between January 2000 and December 2024 were retrospectively evaluated using the PitchBook database (PitchBook Platform, PitchBook Data.
Mathangi Sridharan, Charlotte F. Wahle, Paul Walker, Luke Barry, Jonathan Yu, Frank Petrigliano, Lauren Wessel, Andrew R. Jensen   +7 more
wiley   +1 more source