Results 21 to 30 of about 694,016 (263)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
São Paulo Medical JournalCONTEXT AND OBJECTIVES: The Federal Constitution of 1988 allowed the National Congress to contribute towards formulation of new public policies. The objective of this study was to analyze the legislative production that dealt with health issues that was ...
Viviane Cristina dos Santos +1 more
doaj +1 more source
Investigating the information-seeking behaviour of academic lawyers: From Ellis's model to design. [PDF]
, 2007 Information-seeking is important for lawyers, who have access to many dedicated electronic resources.However there is considerable scope for improving the design of these resources to better support information-seeking.
Ann Blandford +22 more
core +3 more sources
FEBS Open Bio, EarlyView.This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc +8 more
wiley +1 more source
Network Localization of Fatigue in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo +12 more
wiley +1 more source
PLoS ONE, 2021 Following the pioneering efforts of a federal Head Start program, U.S. state policymakers have rapidly expanded access to Early Care and Education (ECE) programs with strong bipartisan support.
Soojin Oh Park, Nail Hassairi
doaj +1 more source
, 2010 As a nation there is probably no greater dividing point for most Americans than the topic of immigration. For the past eight years the American Congress has sought to establish a comprehensive immigration policy and pass sweeping legislation that seeks ...
Estrada, Larry J., Takagi, Midori
core +1 more source
Migration as a Political and Public Phenomenon: The Case of Slovak Republic [PDF]
, 2017 Publication within the project “The V4 towards migration challenges in Europe.
Bolečekova, Martina, Olejarova, Barbora
core +1 more source
Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro +10 more
wiley +1 more source
Promoting global Internet freedom: policy and technology [PDF]
, 2012 This report provides information about US government and private sector efforts to promote and support global Internet freedom and a description of Internet freedom legislation and hearings from the 112th Congress.
Patricia Moloney Figliola
core +6 more sources