Results 31 to 40 of about 218,083 (286)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The accessibility, use, fruition and enrichment of immobile cultural heritage: a review of legislation in Slovenia, Croatia and Italy [PDF]
Studia Universitatis Hereditati, 2017 There are some basic discrepancies between the heritage legislatures of Slovenia, Croatia and Italy. There are important differences in the very constitutional documents; in Slovenia, the concept of preserving cultural heritage is stressed, while Croatia
Katharina Zanier
doaj +1 more source
Fourth Amendment Codification and Professor Kerr\u27s Misguided Call for Judicial Deference [PDF]
, 2005 This essay critiques Professor Orin Kerr\u27s provocative article, The Fourth Amendment and New Technologies: Constitutional Myths and the Case for Caution, 102 Mich. L. Rev. 801 (2004). Increasingly, Fourth Amendment protection is receding from a litany
Solove, Daniel J.
core +2 more sources
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Defining Characteristics and Politicising Victims: A Legal Perspective
Journal of Hate Studies, 2012 Legislatures worldwide experience the same problem in drafting or amending hate crimes statutes: How is it possible to discriminate between victim groups, and which groups are worthy of legislative protection?
Jennifer Schweppe
doaj +1 more source
Legislative strengthening meets party support in international assistance: a closer relationship? [PDF]
, 2009 Recent reports recommend that international efforts to help strengthen legislatures in emerging democracies should work more closely with support for building stronger political parties and competitive party systems.
Brösamle K. +27 more
core +1 more source
FEBS Open Bio, EarlyView.This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc +8 more
wiley +1 more source
Network Localization of Fatigue in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo +12 more
wiley +1 more source
Do Independent Fiscal Institutions Enhance Parliamentary Accountability in the Eurozone?
Politics and Governance, 2021 Independent fiscal institutions (IFIs) have been established or reformed in all eurozone countries following the reform of economic governance. As they are expected to counter the deficit bias of the governments and the information asymmetry of the ...
Cristina Fasone
doaj +1 more source
The Low Water Mark for Beach Access: Defending Government Protection of Intertidal Recreation as a Lawful Exercise of State Power [PDF]
, 2019 Beaches are a natural resource ideally suited for public recreation. The public generally has a right to access this intertidal land, but the purpose and scope of public access vary greatly between states.
Gazikas, Alexander
core +1 more source