Results 111 to 120 of about 52,437 (276)
Clinical and biological factors associated with response to immune checkpoint inhibitors in advanced sarcomas: IMPRESARC, a French retrospective multicenter cohort study
Cancer, Volume 131, Issue 18, 15 September 2025.Abstract Background
Immune checkpoint inhibitors (ICIs) in unselected sarcomas yield limited response rates and tumor control. Long‐term responders have however been reported, suggesting a critical challenge in refining patient selection, by identifying reliable predictive factors for response. Methods
The authors conducted a multicenter, retrospective Mina Fazel, Romain Varnier, Hélène Vanacker, Nicolas Penel, Sarah Watson, Benjamin Verret, Thibaud Valentin, Emmanuelle Bompas, Waisse Waissi, Alexandra Meurgey, Françoise Ducimetière, Jean‐Yves Blay, Armelle Dufresne, Mehdi Brahmi +13 morewiley +1 more sourceBlood‐based biomarkers in soft tissue sarcoma: Implications for immune checkpoint inhibitor therapy
International Journal of Cancer, Volume 157, Issue 6, Page 1031-1042, 15 September 2025.Abstract
Soft tissue sarcoma (STS) is a rare and heterogeneous cancer, comprising approximately 1% of all adult cancers and 7%–15% of all childhood cancers. In the advanced stages, chemotherapy remains the standard‐of‐care, but efficacy is limited, with a response rate of 15%–30%, and responses are often short‐lived, with median progression‐free ...Brie‐Anne Mannah, John J. Park, Su Yin Lim +2 morewiley +1 more sourceOccurrence of splenic leiomyosarcoma in dog: anatomopathological findings
Medicina Veterinária, 2017 Leiomyosarcoma is a malignant neoplasm with origin in smooth muscles. It can originate in the vessel wall and interstitium of the spleen smooth muscle, which is considered rare. The objective of this study was to describe clinical and anatomopathological Thaís de Almeida Moreira, Marcelo Coelho Lopes, Leilane Sousa Santos, Rafael Rocha de Souza, Júnior Artur dos Reis, José Maurício da Rocha Júnior, Márcio de Barros Bandarra +6 moredoaj Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.
Journal of Clinical Oncology, 2016 G. Demetri, M. von Mehren, Robin L. Jones, M. Hensley, S. Schuetze, A. Staddon, M. Milhem, A. Elias, K. Ganjoo, H. Tawbi, B. V. Van Tine, A. Spira, A. Dean, N. Khokhar, Y. Park, R. Knoblauch, T. Parekh, R. Maki, Shreyaskumar R Patel +18 moresemanticscholar +1 more sourceTrabectedin and low-dose radiation therapy in patients with advanced leiomyosarcoma
Therapeutic Advances in Medical OncologyBackground and objectives: Dimensional response is an unmet need in second lines of advanced soft tissue sarcomas (STS). Indeed, the three approved drugs, pazopanib, trabectedin, and eribulin, achieved an overall response rate (ORR) of less than 10 ...Javier Martin-Broto, Alicia Olarte-García, Ricardo Fernandéz-Rodríguez, Marta Ribeiro Ferreira, Irene Carrasco-García, Fernando Galvez-Montosa, Inmaculada Rincon-Perez, Javier Peinado-Serrano, Ignacio Azinovic, Laura Guzman-Gomez, Lurdes Salgado, Alberto Sevillano, Justo Ortega, Cristina Alvarez, Antonio Gutierrez, David S. Moura, Nadia Hindi +16 moredoaj +1 more sourceEribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial
The Lancet, 2016 P. Schöffski, S. Chawla, R. Maki, A. Italiano, H. Gelderblom, E. Choy, G. Grignani, V. Camargo, S. Bauer, S. Rha, J. Blay, P. Hohenberger, D. D’Adamo, M. Guo, B. Chmielowski, A. Cesne, G. Demetri, Shreyaskumar R Patel +17 moresemanticscholar +1 more source