Results 141 to 150 of about 155,594 (285)

Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Schistosomiasis, a neglected tropical disease infecting over 200 million people globally, has limited therapeutic options. The 20S proteasome is a validated drug target for many parasitic infections, including those caused by Plasmodium and Leishmania, and we have previously demonstrated antischistosomal activity with inhibitors targeting ...
Elany B. Silva, Zhenze Jiang, Chenxi Liu, Pavla Fajtová, Thaiz R. Teixeira, Giovana de Castro Fiorini Maia, Lawrence J. Liu, Nelly El‐Sakkary, Danielle E. Skinner, Ali Syed, Steven C Wang, Conor R. Caffrey, Anthony J. O'Donoghue   +12 more
wiley   +1 more source

Leishmania, Herpetomonas, and Crithidia in Fleas [PDF]

, 1920
Carlo Basile
openalex   +1 more source

An Update on the Sand Fly (Diptera: Psychodidae) in Khartoum, Sudan: Species Composition and Distribution in Areas Endemic for Cutaneous Leishmaniasis

Public Health Challenges, Volume 4, Issue 2, June 2025.
An update on the composition and distribution of sand fly species in the Nile environments of Khartoum. Variations were observed in species number than in species composition. The study will be a good reference for future studies on sandflies after the change in their habitat due to the current war in Sudan. ABSTRACT Phlebotomine sand flies are vectors
Suhaib A. Gumaa, Arwa Elaagip, Ehab Frah, Hind Mohamed Abushama   +3 more
wiley   +1 more source

THE CURATIVE VALUE OF LEISHMANIA CULTURE "VACCINE" IN ORIENTAL SORE [PDF]

, 1912
R. Row
openalex   +1 more source

The proinflammatory activity of recombinant serum amyloid A is not shared by the endogenous protein in the circulation.

, 2010
OBJECTIVE: Elevated serum levels of the acute-phase protein serum amyloid A (SAA) are a marker for active rheumatoid arthritis (RA), and SAA can also be found in the tissues of patients with active RA.
Björkman, Lena, Bylund, Johan, Dahlgren, Claes, Karlsson, Anna, Raynes, John G, Shah, Chandrabala   +5 more
core   +1 more source

Coinfección VIH leishmania

Iatreia, 1992
La disminución de las defensas del huésped consecutiva a la Infección por el VIH es la base de las complicaciones oportunistas del paciente con SIDA; una de éstas puede ser la leishmaniosis visceral, reportada recientemente en Brazil, España e Italia. La infección por Leishmania puede tener lugar antes o después de la infección viral.
openaire   +3 more sources

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

THE DEVELOPMENT OF LEISHMANIA DONOVANI IN VITRO AT 37°C [PDF]

, 1953
William Trager
openalex   +1 more source

Spontaneous haemoperitoneum secondary to mast cell neoplasia and presumed splenic abscess rupture in a cat

Veterinary Record Case Reports, Volume 13, Issue 2, June 2025.
Abstract A geriatric feline was presented to a university teaching hospital for lethargy and inappetence. The patient was subsequently diagnosed with spontaneous haemoperitoneum secondary to rupture of a splenic mass and was taken to surgery for splenectomy following appropriate stabilisation measures.
Jenna Collins, Nyssa Levy, Tuddow Thaiwong‐Nebelung   +2 more
wiley   +1 more source

Experiments bearing on the susceptibility of the striped hamster ( Cricetulus griseus ) to Leishmania of Chinese Kala Azar [PDF]

, 1926
Edward Hindle, W. S. Patton
openalex   +1 more source