Results 271 to 280 of about 79,649 (298)

Mechanism of interaction of sitamaquine with Leishmania donovani

Journal of Antimicrobial Chemotherapy, 2010
This study focuses on the mechanism of interaction of sitamaquine with Leishmania donovani membranes, and its accumulation within the parasites.A biomimetic model of the outer layer of a Leishmania plasma membrane was used to examine the interactions of sitamaquine with lipids. The plasma membranes of L.
Pierre Chaminade, A. M. Duenas-Romero, Sandrine Cojean, Philippe M. Loiseau, Audrey Solgadi, D. Libong, L. Le Moyec, L. Le Moyec, Elaine Soares Coimbra, M. Saint-Pierre-Chazalet   +9 more
openaire   +3 more sources

Oxidation of Leucine by Leishmania donovani

The Journal of Protozoology, 1991
ABSTRACT. The metabolism of leucine by Leishmania donovani was investigated. Washed promastigotes were incubated with (1‐14C]‐or [U‐14C]leucine or [1 ‐14C]α‐ketoisocaproate (KIC) and 14C02 release was measured. The amount of KIC‐derived acetyl‐CoA oxidized in the citric acid cycle was computed. Promastigotes from mid‐stationary phase cultures oxidized
openaire   +3 more sources

Secretion of Sucrase by Leishmania donovani

Journal of Eukaryotic Microbiology, 1994
ABSTRACT. Leishmania donovani promastigotes were collected, washed, resuspended in buffer, and assayed for sucrase activity. No activity was observed in the intact washed cells, but activity was measurable when the cells were permeabilized with Triton X‐100.
J. Joseph Blum, Fred R. Opperdoes
openaire   +3 more sources

The activity of hydroxynaphthoquinones against Leishmania donovani

Journal of Antimicrobial Chemotherapy, 1992
The hydroxynaphthoquinones, buparvaquone, 250C80 and 56W82, showed high activity in vitro against Leishmania donovani amastigotes in mouse peritoneal macrophages, with ED50 values of 0.05, 2.95 and 13.82 microM, respectively. Fourteen other hydroxynaphthoquinones were tested, of which only 566C80 and 608C86 showed significant activity against ...
Simon L. Croft, A. T. Hudson, A. W. Randall, J. Hogg, Gutteridge We   +4 more
openaire   +2 more sources

The emergence of Leishmania major and Leishmania donovani in southern Turkey

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2014
In southern Turkey, Leishmania tropica and L. infantum are both the causative agents of cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL), respectively. However, L. major and L. donovani were known to exist after the influx of Syrian refugees.Between the years of July 2003 and July 2013, a total of 167 smears and 113 bone marrow samples were
Koltas I.S., Eroglu F., Alabaz D., Uzun S.   +3 more
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Ultrastructure of the pellicle and the nucleus of Leishmania donovani

1960
In a number of publications (1, 2, 3, 4, 5) from this laboratory from 1951 to 1958, we reported on the phase, electron microscopic and cytochemical observations on Leishmania donovani, the Kala-azar parasite. Using water disruption, acid hydrolysis, and ultra-thin sectioning techniques, a number of protoplasmic constituents of this protozoon were ...
N. N. Das Gupta, Joana Chakraborty
openaire   +2 more sources

Cloning and Characterization of Leishmania donovani Telomeres

Experimental Parasitology, 2000
We describe here the cloning and sequence characterization of the absolute termini of several telomeres from the human parasite Leishmania donovani using a vector-adapter protocol. The 3' protruding strand of L. donovani telomeres terminates with the sequence 5'-GGTTAGGGT-OH 3'.
Kenneth Stuart, Kenneth Stuart, Anita E. Beck, Theo deVos, José Luis Ramírez, Peter J. Myler, Peter J. Myler, Miguel Angel Chiurillo   +7 more
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Cellular Immunity to Leishmania Donovani

The Journal of Immunology, 1974
Abstract C57BL/6J mice were subjected to various combinations of immunosuppressive treatments and infected i.v. with amastigotes of Leishmania donovani. In normal mice the parasite population reached its peak about 24 days post-infection, after which parasite numbers gradually declined but they were still detectable on day 60. The course
Clare B Skov, Donald W Twohy
openaire   +1 more source

Leishmania donovani (Ross 1903) [PDF]

, 1995
Visceral leishmaniasis, also known as kala-azar, has a wide distribution; no accurate estimate of its prevalence is currently available. The protozoan species that causes visceral leishmaniasis varies according to geographic regions; each has its own unique sandfly vectors and resevoir hosts.1 In India, Bangladesh, Nepal, and China the infection is ...
Robert W. Gwadz, Dickson D. Despommier, Peter J. Hotez   +2 more
openaire   +1 more source

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi.

Journal of Natural Products, 2016
Dehydroabietylamine (1) was used as a starting material to synthesize a small library of dehydroabietyl amides by simple and facile methods, and their activities against two disease-causing trypanosomatids, namely, Leishmania donovani and Trypanosoma ...
Minni Pirttimaa, A. Nasereddin, Dmitry Kopelyanskiy, M. Kaiser, J. Yli-Kauhaluoma, K. Oksman‐Caldentey, R. Brun, C. Jaffe, V. Moreira, S. Alakurtti   +9 more
semanticscholar   +1 more source