Results 61 to 70 of about 20,249 (182)
ABSTRACT Background and Aim Maple Syrup Urine Disease (MSUD) is a metabolic disorder affecting branched‐chain amino acid metabolism. While neurological symptoms are well‐characterized, cutaneous manifestations such as acrodermatitis dysmetabolica (AD) caused by isoleucine deficiency remain underrecognized.
Bahareh Abtahi‐naeini +4 more
wiley +1 more source
Synthesis and biological evaluation (antibacterial, antifungal, anti‐tuberculosis, antiprotozoal) and in silico molecular docking of biphenyl ether based Schiff's base analogues. ABSTRACT In order to investigate their possible biological activity, a number of new Schiff base compounds based on diaryl ether, specifically 2‐(substituted‐arylamino)‐N′‐(3 ...
Navin B. Patel +7 more
wiley +1 more source
Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery
Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá +4 more
wiley +1 more source
New anthranilate–naphthoquinone hybrids display potent inhibition of Leishmania (L.) amazonensis with low host cell toxicity. Molecular docking reveals key interactions with TR, GP63, and PTR1, suggesting a multitarget mechanism that contributes to parasite death.
Eduardo Miranda da Silva Magesfeste +7 more
wiley +1 more source
Mini-Exon Genotyping of Leishmania Species in Khuzestan Province, Southwest Iran [PDF]
Background: Leishmaniasis is a protozoan disease cause by Leishmania genus. Anthroponotic and zoonotic cutaneous leishmaniasis are endemic in Iran. The aim of this study was to identify the causative agent of cutaneous leishmaniasis by mini-exon gene in
J Saki +7 more
doaj +1 more source
Symmetrical Cutaneous Leishmaniasis
Sir, Cutaneous leishmaniasis (CL) is a protozoan disease present in Old and New Worlds (1, 2). It is endemic in the Mediterranian basin, particularly in the rural areas of Sicily where almost 60% of Italian cases occur. The disease is caused by parasites of the genus Leishmania infantum, carried by specific species of sandflies as Phlebotomus ...
GUARNERI, Claudio +1 more
openaire +2 more sources
A Declining Trend of 'Leishmaniasis' Based on Previous Data in Larstan, South of Iran 2007–2017
Introduction: 'Cutaneous Leishmaniasis' is a unicellular of the Leishmania type, and 0.7 to 1.2 million people are annually infected by 'Cutaneous Leishmaniasis'. Larestan is one of the southern cities of Fars Province.
Ahmad Abolghazi +4 more
doaj +1 more source
Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis
The human T cell lymphotropic virus type-1 (HTLV-1) is associated with adult T cell leukemia/lymphoma (ATL) and other disorders, including a slowly progressive demyelinating paraparesis, known as HTLV-1-associated myelopathy/tropical spastic paraparesis (
Reza Boostani +8 more
doaj
Cutaneous leishmaniasis in Iraq
To determine the incidence ofcutaneous leishmaniasis (CL) in Alhaweja District and to clarify the secondary bacterial infection inCL.A prospective survey was performed in the outpatient clinic of Alhaweja General Hospital. All the patients who presented at the dermatology clinic during the period from 1 October 2004 to the end of April 2005 were ...
Abdulghani Mohamad AlSamarai +1 more
openaire +4 more sources
Rifampicin in Cutaneous Leishmaniasis
A study is described which aimed at assessing the efficacy of rifampicin in the treatment of cutaneous leishmaniasis. A total of thirteen patients suffering from this condition were admitted to the study and were given rifampicin 600 mg daily. Three patients dropped out due to reasons unconnected with the trial and one patient left when the lesions ...
openaire +2 more sources

