Results 61 to 70 of about 6,377 (212)

Localised Leishmaniasis of Oral Mucosa: Report of an Unusual Clinicopathological Entity

Case Reports in Dentistry, 2014
The term leishmaniasis comprises of a group of diseases caused by different species of a protozoan called Leishmania. There are three main clinical forms of leishmaniasis: visceral leishmaniasis, cutaneous leishmaniasis, and mucocutaneous leishmaniasis ...
Deepak Passi, Sarang Sharma, Shubharanjan Dutta, Chandan Gupta   +3 more
doaj   +1 more source

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

Brief communication: Vitamin D serum levels in American tegumentary leishmaniasis from an endemic area in Northeast Brazil

Brazilian Journal of Infectious Diseases, 2023
Introduction: The pathogenesis of cutaneous and mucosal leishmaniasis is associated with different immune responses. Vitamin D may modulate the immune system. Here we evaluate the association of vitamin D levels with the severity of the clinical forms of
Lorena Pinheiro Figueiredo, Thiago Cerqueira-Silva, Andréa Magalhães, Ednaldo Lima Lago, Marcus Miranda Lessa   +4 more
doaj   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1087-1097, April 2026.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Clinical pattern and treatment outcome of cutaneous leishmaniasis patients in Somali region, eastern Ethiopia

Skin Health and Disease
Background Neglected tropical diseases, affecting over a billion people, include leishmaniasis, a protozoan parasite found in over 20 species. It is classified into three types: visceral, cutaneous, and muco‐cutaneous leishmaniasis, with cutaneous ...
Abdilahi Ibrahim Muse, Muse Obsiye Ibrahim, Muse Ahmed Ibrahim   +2 more
doaj   +1 more source

Comparative features of 166 cases of cutaneous, mucocutaneous and mucosal leishmaniasis by main infecting complex species.

, 2021
Comparative features of 166 cases of cutaneous, mucocutaneous and mucosal leishmaniasis by main infecting complex species.
Jan Clerinx (451975), Christophe Ravel (334517), Laurence Lachaud (2636371), Leo Visser (35429), Stephen L. Walker (7879070), Gundel Harms (158799), Diana N. Lockwood (11559675), Pierre Buffet (82569), Pieter Van Thiel (11559669), Romain Guery (4604179), Sara Karlsson Söbirk (11559672), Mark Bailey (136051), Johannes Blum (141240), Gert Van der Auwera (351827), Andreas Neumayr (198330), Jean-Pierre Gangneux (177380), Aldert Bart (14872)   +16 more
core   +1 more source

Progress of Mucocutaneous Leishmaniasis to Drug Nonresponsive Diffuse Cutaneous Leishmaniasis in Ethiopia. A Case Report

International Medical Case Reports Journal, 2020
Banchamlak Tegegne,1 Getaneh Alemu2 1Amhara Public Health Institute, Bahir Dar, Ethiopia; 2Department of Medical Laboratory Science, Bahir Dar University, Bahir Dar, EthiopiaCorrespondence: Getaneh Alemu PO Box 79 Tel +251922842776Email getanehmlt@gmail ...
Tegegne B, Alemu G
doaj  

Is the Clinical Diagnosis of Cutaneous Leishmaniasis Justified in Endemic Regions?

مجله كليه طب الكندي, 2023
Leishmaniasis is a transmissible infection brought about by an obligatory intracellular protozoan from the genus Leishmania.  It occurs worldwide in tropical and subtropical regions and can be burdensome in resource-constrained countries.
Mahmood D. Al-Mendalawi
doaj   +1 more source

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +1 more source

Mucocutaneous Leishmaniasis with Oral Manifestation: Case Report [PDF]

, 2020
La Leishmaniasis es un grupo de enfermedades transmitidas por vectores y causada por la Leishmania, un parásito intracelular, que se presenta de preferencia en regiones tropicales y subtropicales. Se manifiesta mediante un amplio rango de formas clínicas
Pimentel Sola, Juan Martin, Marco, Jorge Diego, Brunetto, Guadalupe, Córdoba, Mauree, Molina Avila, Ignacio Javier, Cordero Torres, Karina, Garcia Bustos, Maria Fernanda, Pimentel Solá, María Julia   +7 more
core   +1 more source