Results 11 to 20 of about 32,959 (195)

Matematisering i lek på vetenskaplig grund

Nordisk Barnehageforskning, 2023
I den här artikeln riktar vi uppmärksamhet mot uttrycket matematisera, myntat av matematikdidaktikern Hans Freudenthal och ofta använt i beskrivningar av förskolebarns matematiklärande.
Camilla Björklund, Hanna Palmér
doaj   +1 more source

Biopharmaceutical classification of desloratadine – not all drugs are classified the easy way

Acta Pharmaceutica, 2020
The biopharmaceutical classification of drugs was designed as a basis for bio-waivers – a mechanism with the double ethical benefit of delivering new drug formulations to the market with less human testing and lower cost.
Berginc Katja, Sibinovska Nadica, Žakelj Simon, Trontelj Jurij, Legen Igor   +4 more
doaj   +1 more source

On the Stability and Degradation Pathways of Venetoclax under Stress Conditions

Pharmaceutics, 2020
Venetoclax is an orally bioavailable, B-cell lymphoma-2 (BCL-2) selective inhibitor, used for the treatment of various types of blood cancers, such as chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).
Nina Žigart, Martin Črnugelj, Janez Ilaš, Zdenko Časar   +3 more
doaj   +1 more source

Ikke dårligere enn før, men annerledes: En generasjonsstudie av lek i barndommen

Barn, 2021
I denne artikkelen beskriver vi lek gjennom et historisk perspektiv basert på tre generasjoners minner fra barndommen i Norge. De tre generasjonene er de som i perioden 2019–2020 var mellom 70–80, 50–60 og 20–30 år.
Gunilla Eide Isaksen, Ragnhild Norderhus, Maria Øksnes   +2 more
doaj   +1 more source

Optimization of UPLC method for simultaneous determination of rosuvastatin and rosuvastatin degradation products

Acta Chimica Slovenica, 2017
An ultra-performance liquid chromatographic method for simultaneous determination of rosuvastatin and rosuvastatin degradation products was developed and optimized by using fractional factorial experimental design.
Jure Zakrajšek, Katarina Bevc-Černilec, Simona Bohanec, Uroš Urleb   +3 more
doaj   +2 more sources

Female preference and predation risk models can explain the maintenance of a fallow deer (Dama dama) lek and its 'handy' location.

PLoS ONE, 2014
We tested the predictions of three models (female preference; hotspot; predator avoidance) on lek formation in the fallow deer population of San Rossore, Tuscany.
Marco Apollonio, Fabio De Cena, Paolo Bongi, Simone Ciuti   +3 more
doaj   +1 more source

Multivariate quantitative analysis of glycan impact on IgG1 effector functions

mAbs
Development of novel therapeutic proteins and biosimilars requires a thorough understanding of the relationship between their structure and function. Particularly, how IgG glycosylation affects its effector functions is a point increasingly underscored ...
Tamara Cvijić, Matej Horvat, Jakob Plahutnik, Ana Golob, Jaka Marušič   +4 more
doaj   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Mer enn bare kreativitet: en utforskende studie av lek i arbeidslivet

Norsk Sosiologisk Tidsskrift
Forskning på lek i arbeidslivet har primært fokusert på kreativitet og innovasjon i yrker med høyere utdanning. Dette har ført til en slagside i litteraturen, der andre former for lek har vært mindre belyst. Denne artikkelen har en utforskende tilnærming
Marcus Wedvik, Kristoffer Chelsom Vogt
doaj   +1 more source

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered ...
Edna Karla Ferreira Laurentino, Marina Lyra L. C. Fagundes, Bruno Lobão Soares, Rodrigo Torres‐Castro, Matias Otto‐Yañez, Emerson Arcoverde Nunes, Matheus Freitas Fernandes Pedrosa, Jéssica Danielle Medeiros da Fonsêca, Vanessa R. Resqueti, Guilherme Augusto de Freitas Fregonezi   +9 more
wiley   +1 more source