Results 21 to 30 of about 23,825 (81)

Nucleotide-sugar metabolism in plants: the legacy of Luis F. Leloir.

open access: yesJournal of Experimental Botany, 2021
This review commemorates the 50th anniversary of the Nobel Prize in Chemistry awarded to Luis F. Leloir 'for his discovery of sugar-nucleotides and their role in the biosynthesis of carbohydrates'. He and his co-workers discovered that activated forms of
C. M. Figueroa, J. Lunn, A. Iglesias
semanticscholar   +1 more source

The Leloir Cycle in Glioblastoma: Galactose Scavenging and Metabolic Remodeling

open access: yesCancers, 2021
Simple Summary Proliferation of glioblastoma (GBM) depends on access to extracellular nutrients. Inadequate tumor perfusion creates a short supply of the most common nutrients, such as glucose (Glc) and glutamine.
M. Sharpe   +5 more
semanticscholar   +1 more source

Side Chain Conformation Restriction in the Catalysis of Glycosidic Bond Formation by Leloir Glycosyltransferases, Glycoside Phosphorylases, and Transglycosidases.

open access: yesACS Catalysis, 2021
Carbohydrate side chain conformation is an important factor in the control of reactivity at the anomeric center, ie, in the making and breaking of glycosidic bonds, whether chemically or, for hydrolysis, by glycoside hydrolases. In nature glycosidic bond
Jo Quirke, D. Crich
semanticscholar   +1 more source

Selective β-Mono-Glycosylation of a C15-Hydroxylated Metabolite of the Agricultural Herbicide Cinmethylin Using Leloir Glycosyltransferases

open access: yesJournal of Agricultural and Food Chemistry, 2021
Cinmethylin is a well-known benzyl-ether derivative of the natural terpene 1,4-cineole that is used industrially as a pre-emergence herbicide in grass weed control for crop protection.
Jihye Jung   +4 more
semanticscholar   +1 more source

Leloir glycosyltransferases enabled to flow synthesis: Continuous production of the natural C‐glycoside nothofagin

open access: yesBiotechnology and Bioengineering, 2021
C‐glycosyltransferase (CGT) and sucrose synthase (SuSy), each fused to the cationic binding module Zbasic2, were co‐immobilized on anionic carrier (ReliSorb SP400) and assessed for continuous production of the natural C‐glycoside nothofagin.
H. Liu, B. Nidetzky
semanticscholar   +1 more source

The Metabolic Chemical Reporter Ac46AzGal Could Incorporate Intracellular Protein Modification in the Form of UDP-6AzGlc Mediated by OGT and Enzymes in the Leloir Pathway

open access: yesFrontiers in Chemistry, 2021
Galactose is a naturally occurring monosaccharide used to build complex glycans that has not been targeted for labeling as a metabolic reporter. Here, we characterize the cellular modification of proteins by using Ac46AzGal in a dose- and time-dependent ...
Jiajia Wang   +11 more
semanticscholar   +1 more source

Conhecimento do formador de professores de matemática que é investigador da docência

open access: yesZetetike, 2021
Neste trabalho, o objetivo é compreender o conhecimento do formador de professores de Matemática que é investigador da docência e toma a docência e a formação de professores como objeto de estudo. A pesquisa se configura como um estudo de caso de caráter
F. Coura, C. Passos
semanticscholar   +1 more source

Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications [PDF]

open access: yesScience Signaling 12 Jan 2021: Vol. 14, Issue 665, eabd0334, 2020
The primary cell surface receptor for SARS-CoV-2 is the angiotensin-converting enzyme 2 (ACE2). Recently it has been noticed that the viral Spike protein has an RGD motif, suggesting that cell surface integrins may be co-receptors. We examined the sequences of ACE2 and integrins with the Eukaryotic Linear Motif resource, ELM, and were presented with ...
arxiv   +1 more source

Hacia el fiscal investigador: un recorrido histórico

open access: yesRevista de las Cortes Generales, 2021
El debate sobre el cambio de modelo en la fase de instrucción del proceso penal pasando de la tradicional función instructora atribuida a los jueces conforme al modelo propuesto por la Ley de Enjuiciamiento Criminal de 1882, al de un fiscal investigador ...
Eduardo Torres-Dulce Lifante
semanticscholar   +1 more source

The evolution of the GALactose utilization pathway in budding yeasts [PDF]

open access: yesarXiv, 2021
The Leloir galactose utilization or GAL pathway of budding yeasts, including that of the baker's yeast Saccharomyces cerevisiae and the opportunistic human pathogen Candida albicans, breaks down the sugar galactose for energy and biomass production. The GAL pathway has long served as a model system for understanding how eukaryotic metabolic pathways ...
arxiv  

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