Results 101 to 110 of about 220,715 (308)

The impacts of muscle-specific force-velocity properties on predictions of mouse muscle function during locomotion

Frontiers in Bioengineering and Biotechnology
Introduction: The accuracy of musculoskeletal models and simulations as methods for predicting muscle functional outputs is always improving. However, even the most complex models contain various assumptions and simplifications in how muscle force ...
James P. Charles, Roger W. P. Kissane, Graham N. Askew   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Clinical implementation of MRI for evaluation of titanium press-fit osseointegration implants

OTA International
. Objective:. This investigation of the safety of titanium transcutaneous osseointegrated nail (TiTON) implants in a magnetic resonance imaging (MRI) suite evaluated whether any adverse events occurred for patients (pain, heating sensation, implant ...
LaYow C. Yu, BA, Tyler D. DeSena, BA, Alissa J. Burge, MD, S. Robert Rozbruch, MD, Taylor J. Reif, MD, Jason S. Hoellwarth, MD   +5 more
doaj   +1 more source

Issues in Balto-Slavic accentology [PDF]

, 2010
After the very well-organized Leiden conference for which we must be grateful to Tijmen Pronk, it seems appropriate for me to review some of the papers, as I did after the previous conferences in Zagreb and Copenhagen. The aim of this review is merely to
Kortlandt, Frederik H. H.
core  

Dynamical approach to chains of scatterers

, 2007
Linear chains of quantum scatterers are studied in the process of lengthening, which is treated and analysed as a discrete dynamical system defined over the manifold of scattering matrices.
Abrahams E, Andereck B S, Cohen-Tannoudji C, Cwilich G A, Dorokhov O N, Elliott J, Feller W, Horvat M, Kirkman P D, Kramer B, Londergan J T, Martin Horvat, Newton R G, Reichl L E, Scott W R, Tomaž Prosen   +15 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Surgeon\u27s perspective on short bowel syndrome: Where are we? [PDF]

, 2018
Short bowel syndrome (SBS) is due to a massive loss of small bowel: the reduction of gut function is below the minimum necessary to maintain health (in adults) and growth (in children) so intravenous supplementation is required.
Lauro, Augusto, Marino, Ignazio R.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

New insights in gill/buccal rhythm spiking activity and CO2 sensitivity in pre- and post-metamorphic tadpoles (Pelophylax ridibundus)

, 2013
Central CO2chemosensitivity is crucial for all air-breathing vertebrates and raises the question of itsrole in ventilatory rhythmogenesis. In this study, neurograms of ventilatory motor outputs recorded infacial nerve of premetamorphic and ...
Fiamma, Marie-Noëlle, Horcholle-Bossavit, Ginette, Quenet, Brigitte, Rivals, Isabelle, Similowski, Thomas, Straus, Christian   +5 more
core   +3 more sources