Results 91 to 100 of about 6,740 (242)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Desmoplastic Melanoma Arising after 1,064 nm q-Switched Nd:YAG Laser of a Suspected Solar Lentigo

Case Reports in Dermatological Medicine, 2019
Objectives. To present a case of desmoplastic melanoma (DM) arising after laser therapy of a suspected solar lentigo with the 1,064 nm Q-switched (QS) Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser and discuss the safety of treating suspected solar ...
Leah Cohen, Sonali Nanda, Martin Zaiac
doaj   +1 more source

Lentigo maligno na face: um desafio na conduta

Revista Brasileira de Oftalmologia
Resumo O lentigo maligno é um melanoma in situ, de crescimento radial e lento, que acomete áreas fotoexpostas principalmente em idosos. Quando acomete a pálpebra, devido à proximidade a um órgão nobre, a conduta é controversa, porém a cirurgia é o método
Cíntia da Silva Gomes, Isabella Farias Glória de Paiva Barroso, Thaisa Bastos de Sousa Dutra, Daniel Lago Obadia, Tainá Scalfoni Fracaroli   +4 more
doaj   +1 more source

Lentiginous eruption in resolving psoriasis plaques during treatment with ixekizumab: a case report and review of the literature

Dermatology Reports, 2017
We report the case of a 56-year old male with severe plaque psoriasis that was successfully treated with ixekizumab, a new anti interleukin (IL)-17 monoclonal antibody. During the first months of treatment he developed a lentiginous eruption in the sites
Pablo Santa María, Fernando Valenzuela, Claudia Morales, Raul De la Fuente, Roberto Cullen   +4 more
doaj   +1 more source

Optimizing Diagnostic Accuracy of Clinical Red Flags in RASopathies

American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1608-1618, July 2026.
ABSTRACT RASopathies are a group of genetic disorders caused by pathogenic variants in the RAS‐mitogen‐activated protein kinase (RAS–MAPK) signaling pathway, often presenting with congenital heart defects, craniofacial dysmorphisms, and developmental delays. To assess the diagnostic yield of genetic testing in patients with suspected RASopathies and to
Emanuele Bobbio, Martina Caiazza, Emanuele Monda, Giustina Aruta, Alberto Budillon, Augusto Esposito, Adelaide Fusco, Annapaola Cirillo, Marta Rubino, Immacolata Viscovo, Gioacchino Scarano, Matteo Della Monica, Vincenzo Nigro, Giulio Piluso, Leandro Pecchia, Maria Giovanna Russo, Giuseppe Limongelli   +16 more
wiley   +1 more source

Comparison of 1064‐nm Picosecond and Q‐Switched Neodymium‐Doped Yttrium Aluminum Garnet Lasers for Melasma in Asian Women: A Randomized Double‐Blind Split‐Face Trial

Journal of Cosmetic Dermatology, Volume 25, Issue 7, July 2026.
ABSTRACT Background Melasma is a chronic, relapsing facial hyperpigmentation that remains challenging to treat in medium‐to‐dark phototypes. Aims To compare the efficacy, safety, tolerability, and recurrence of 1064‐nm picosecond neodymium‐doped yttrium aluminum garnet laser treatment versus 1064‐nm Q‐switched neodymium‐doped yttrium aluminum garnet ...
Ying Wu, Qixuan Wang, Jiayi Feng, Zehua Chen, Lvping Huang, Yongqiang Feng, Xiaojing Li   +6 more
wiley   +1 more source

Reflectance confocal findings in a large-cell acanthoma with histologic correlation

JAAD Case Reports, 2021
Alli J. Blumstein, BS, Katharine L. Hanlon, BFA, Wei-Shen Chen, MD, George Elgart, MD, James M. Grichnik, MD, PhD, Lilia Correa-Selm, MD   +5 more
doaj   +1 more source

Preclinical and Virtual Models of Mucosal Melanoma: Bridging Translational Gaps in a Rare and Lethal Cancer

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
Integrated physical and virtual modeling provides a scalable framework to overcome sample scarcity, recapitulate mucosal melanoma biology, and accelerate translational discovery toward precision medicine. ABSTRACT Mucosal melanoma (MM) is a rare and lethal subtype of melanoma, disproportionately affecting Asian populations and exhibiting distinct ...
Xiangjie Jin, Yuhan Zhang, Yuantai Zhu, Zhiyuan Zhang, Chaoji Shi   +4 more
wiley   +1 more source

Desmoplastic melanoma associated with an intraepidermal lentiginous lesion: case report and literature review Melanoma desmoplásico associado a lesão lentiginosa intraepidérmica, com evolução de 10 anos: relato de caso e revisão bibliográfica

Anais Brasileiros de Dermatologia, 2013
Desmoplastic melanoma tends to present as firm, amelanotic papules. Microscopically, it reveals a proliferation of fusiform cells in the dermis and variable collagen deposition, as well as intraepidermal melanocytic proliferation of lentiginous type in ...
Cesar de Souza Bastos Junior, Juan Manuel Piñeiro-Maceira, Fernando Manuel Belles de Moraes   +2 more
doaj  

Pharmacy‐based triage to preselect high‐risk individuals for skin cancer screening: A pilot study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
An Buckinx, Laurence Feldmeyer, Philippa Golling, Carlo Mainetti, Cristina Mangas, Anja Wysocki, Véronique Del Marmol, Regina von Burg, Eva von Wartburg, Stephen P. Jenkinson, Daniel Hohl, Olivier Gaide   +11 more
wiley   +1 more source