Results 41 to 50 of about 6,740 (242)

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, EarlyView.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source

Lentigo treated by Sepia officinalis – A case report

, 2022
Introduction: Lentigo is a benign pigmented macular lesion on the skin with a clearly defined margin. It can affect both genders, all ages and races. Solar lentigines are especially prevalent in fair-skinned adults.
Das, Subhrasankha, Madhumita Sadhukhan, Chittaranjan Kundu, Kundu, Chittaranjan, Sadhukhan, Madhumita, Subhrasankha Das   +5 more
core   +1 more source

Giving Up

Journal of Applied Philosophy, EarlyView.
ABSTRACT Philosophical accounts of long‐term goals focus predominantly on the rationality of perseverance, examining when agents should persist despite evidence of failure. Arguably, these accounts consider that giving up is devoid of value. Conversely, this article argues that giving up has a different epistemic function: generating information about ...
Mario I. Juarez‐Garcia
wiley   +1 more source

Lentigo maligna and contiguous pigmented lesion

, 2013
Lentigo malina, melanoma in-situnun alt tipidir. Genellikle 50-80 yaş arasında görülür ve deri kanserlerinin %10 ile 15’ ini oluşturur. LM, atipik, pigmente, maküler lezyonların geleneksel tanımıdır.LM aşırı güneş hasarlanmasıyla oluşur. Genellikle yaşlı
Uzunlar, Ali Kemal, Turan, Hakan, Aliağaoğlu, Cihangir, Erdem, Havva, Yıldırım, Ümran   +4 more
core   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Double blade scalpel: an option for use in the spaghetti technique for Mohs surgery with paraffin embedded sections for lentigo maligna

, 2020
El abordaje quirúrgico del lentigo maligno es un desafío para los Dermatólogos, dada la dificultad para delimitar los bordes de la lesión. En el manejo quirúrgico del lentigo maligno, se ha empleado la escisión de los bordes visibles mediante la técnica ...
Jaimes Ramirez, Ángel Omar, Pulido- Prieto, Leonardo, Barrera, Juan Camilo   +2 more
core   +1 more source

A case report of Peutz–Jeghers syndrome in a child with Crohn's disease

JPGN Reports, EarlyView.
Abstract Peutz–Jeghers syndrome (PJS) is a rare genetic disorder characterized by hamartomatous polyps and mucocutaneous hyperpigmented freckles, whereas Crohn's disease (CD) is a condition characterized by chronic intestinal inflammation. Here, we present a rare case report of an 11‐year‐old male who presented with both CD and PJS.
Hasala Rannulu, Eve May, Bethany Cunningham, Eric Cochran, Rachel Zdenek, Stefany H. Garrity   +5 more
wiley   +1 more source

Unstable solar lentigo: a defined separate entity

, 2016
An unstable solar lentigo is a solar lentigo with areas of melanocytic hyperplasia not extending past the margin of the lesion. They are discrete, macular, pigmented lesions arising on sun-damaged skin and a subset of typical solar lentigos.
Barksdale, S., Muir, J., Byrom, L., Weedon, D.   +3 more
core   +1 more source

Long‐Term Clinical Response After Low‐Dose and Short‐Duration Cemiplimab Therapy in a Patient With Xeroderma Pigmentosum in Nepal

JEADV Clinical Practice, EarlyView.
ABSTRACT Xeroderma pigmentosum (XP), an autosomal recessive condition affecting DNA repair, is associated with a high risk of multiple and aggressive cutaneous squamous cell carcinomas (CSCCs). Because of numerous and/or locally advanced tumors, surgery may be difficult.
Sudip Parajuli, Arnab Panta, Sabina Bhandari, Anne Grange, Florent Grange, Upama Paudel   +5 more
wiley   +1 more source

Lentigo maligna in a young adult

, 2008
Background: Lentigo maligna is mainly diagnosed in the elderly with severely sun-damaged skin. Observation: We describe a case of lentigo maligna in a 51-year-old woman with Fitzpatrick skin type III.
Ferrara G, Mordente I, ARGENZIANO, Giuseppe, Zalaudek I, Ligrone L   +4 more
core   +2 more sources