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Anti-Cancer Effects of Clofazimine As a Single Agent and in Combination with Cisplatin in Multiple Myeloma

, 2016
Multiple myeloma (MM) is a malignant neoplasm of bone marrow plasma B cells with high morbidity. Clofazimine (CLF) is an FDA-approved leprostatic, anti-tuberculosis, and anti-inflammatory drug that was previously shown to have growth suppression effects ...
Aliye Ezgi Gulec +6 more
core +1 more source

The Role of Macrophages in the Sequestration of Drug and Formation of Insoluble Drug Aggregates [PDF]

, 2018
Drugs with poor aqueous solubility generally possess unfavorable pharmacokinetic properties. Upon oral administration, such drugs can form supersaturated solutions within the gastrointestinal tract, causing the formation of insoluble aggregates which may
Rzeczycki, Phillip
core

Üre/tiyoüre grupları taşıyan sakarın ve isatin türevlerinin sentezi ve polifenol oksidaz enzim inhibisyonlarının incelenmesi [PDF]

, 2012
06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması ...
Sönmez, Fatih
core

Mitochondrial calcium uptake pathways as a potential therapeutic target [PDF]

, 2016
It has been known since the 1960’s that mitochondria have a huge capacity to take up and accumulate calcium from the cytosol, regulating energy production, autophagy, and mitochondrial morphology.
Hill, JM
core

Assessment of Clinical, Histopathological, and Bacteriological Findings in Treated Leprosy Patients with Persistent Skin Lesions: A Retrospective Cohort Study. [PDF]