Results 361 to 370 of about 324,634 (386)

Leptin-Signaling Pathways and Leptin Resistance

2009
Leptin acts as an anorexigenic hormone in the brain, where the long form of the leptin receptor (LRb) is widely expressed in hypothalamic and extra-hypothalamic sites that are known to participate in diverse feeding circuits. The important role of leptin in energy homeostasis is demonstrated by the profound hyperphagia and morbid obesity in humans and ...
openaire   +2 more sources

Biological action of leptin as an angiogenic factor.

Science, 1998
Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) is expressed primarily in the hypothalamus. Here, it is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial cells.
M. R. Sierra-Honigmann, Anjali K. Nath, Chiaki Murakami, G. Garcı́a-Cardeña, G. Garcı́a-Cardeña, A. Papapetropoulos, W. Sessa, L. Madge, J. Schechner, M. Schwabb, P. Polverini, J. Flores-Riveros   +11 more
semanticscholar   +1 more source

Immunoassays for Leptin and Leptin Receptors

2006
Availability of methods for accurate and reproducible quantification of lepth in various biological fluids in humans and in animals has greatly facilitated research leading to the understanding of its role in various physiological and pathophysiological conditions. Immunoassay techniques provide a simple and robust tool for measurement of biomolecules.
openaire   +2 more sources

Serum leptin levels, skin leptin and leptin receptor expression in psoriasis

British Journal of Dermatology, 2008
Recent studies support the relation of psoriasis with obesity and cardiovascular disease. Leptin, a peptide hormone secreted predominantly from adipose tissue, is involved in the regulation of energy intake and expenditure. Recently, it has been shown to have several immunological effects including induction of proinflammatory cytokine production.To ...
Mehmet Onur Elbasi, Aydin Sav, Tulin Ergun, Aysin Tulunay, Süheyla Uyar Bozkurt, Aslı Aksu Çerman   +5 more
openaire   +3 more sources

Leptin and Aldosterone

2019
The prominence of obesity in the clinical population as well as the strong association of cardiovascular risk factors with obesity has prompted the investigation of the adipose tissue and its physiological contribution to cardiovascular health. A notable finding in these investigations was the discovery of the adipocyte-derived hormone leptin.
Jessica L. Faulkner, Eric J. Belin de Chantemèle   +1 more
openaire   +3 more sources

Leptin and the regulation of body weight in mammals

Nature, 1998
J. Friedman, J. Halaas
semanticscholar   +1 more source

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Nature Network Boston, 1995
M. Maffei, J. Halaas, E. Ravussin, R. Pratley, Gwo-Hwa Lee, Gwo-Hwa Lee, Yuhong Zhang, Yuhong Zhang, Hong Fei, S. Kim, R. Lallone, S. Ranganathan, P. Kern, J. Friedman, J. Friedman   +14 more
semanticscholar   +1 more source

Role of leptin in the neuroendocrine response to fasting

Nature, 1996
R. Ahima, Daniel Prabakaran, C. Mantzoros, D. Qu, B. Lowell, E. Maratos-Flier, J. Flier   +6 more
semanticscholar   +1 more source

Leptin

2016
Leptin is an adipose-derived hormone and consists of 146 aa residues. Leptin is involved in several functions such as feeding, thermogenesis, fertilization, and hormonal secretion. Leptin binds to leptin receptors and activates intracellular signaling pathways such as JAK-STAT, PI3/Akt, and MAPK.
openaire   +2 more sources

A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue

Nature, 2020
Putianqi Wang, Ken H. Loh, Michelle Wu, D. Morgan, Marc Schneeberger, Xiaofei Yu, Jingyi Chi, C. Kosse, Damian Kim, K. Rahmouni, P. Cohen, J. Friedman   +11 more
semanticscholar   +1 more source