Results 61 to 70 of about 1,122,757 (208)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Análisis del perfil de flexibilidad en jóvenes taekwondistas
Revista de Artes Marciales Asiáticas, 2018 El objetivo principal del presente estudio fue determinar el perfil de flexibilidad de la extremidad inferior en atletas jóvenes de taewwondo, así como identificar los deportistas con cortedad muscular.
Antonio Cejudo Palomo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Revista de la Asociación Argentina de Ortopedia y TraumatologíaIntroducción: Existen múltiples enfoques quirúrgicos para abordar las lesiones del bíceps distal, con diferentes tasas de éxito y complicaciones asociadas.
Ignacio Seré +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Gerokomos, 2018 RESUMEN La quemadura es una lesión térmica multicausal que afecta a diferentes tejidos corporales. En miembro inferior se complican con síndrome posflebítico, cicatrices retráctiles y disfunciones motoras, por lo que el diagnóstico precoz y el ...
Jordi Guinot-Bachero +4 more
doaj
Revista del Hospital Italiano de Buenos AiresIntroducción: aquellas personas con buen control de tronco poseen una mayor probabilidad de realizar por sí mismas actividades de la vida diaria independientemente del nivel de lesión y del grado de lesión; pero hasta el momento no contamos en la ...
Gerardo Candoni +3 more
doaj +1 more source