Results 51 to 60 of about 1,144,301 (208)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Análisis del perfil de flexibilidad en jóvenes taekwondistas

Revista de Artes Marciales Asiáticas, 2018
El objetivo principal del presente estudio fue determinar el perfil de flexibilidad de la extremidad inferior en atletas jóvenes de taewwondo, así como identificar los deportistas con cortedad muscular.
Antonio Cejudo Palomo, Blanca San Cirilo Soriano, Francisco Javier Robles Palazón, María Del Pilar Saiz De Baranda   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Reparación anatómica del bíceps distal por un abordaje anterior sin el uso de implantes: resultados clínicos y funcionales

Revista de la Asociación Argentina de Ortopedia y Traumatología
Introducción: Existen múltiples enfoques quirúrgicos para abordar las lesiones del bíceps distal, con diferentes tasas de éxito y complicaciones asociadas.
Ignacio Seré, Santiago Llumipanta, Juan Carrizo, Natalia Villa, Marcos Deimundo, Enrique Gobbi   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

La importancia del tratamiento inicial adecuado en una quemadura subdérmica en miembro inferior. Caso clínico

Gerokomos, 2018
RESUMEN La quemadura es una lesión térmica multicausal que afecta a diferentes tejidos corporales. En miembro inferior se complican con síndrome posflebítico, cicatrices retráctiles y disfunciones motoras, por lo que el diagnóstico precoz y el ...
Jordi Guinot-Bachero, Adrián García-Montero, Nuria Martínez-Blanco, Soledad Viedma-Contreras, Yolanda Gombau-Baldrich   +4 more
doaj  

Validez de constructo y utilidad clínica del Trunk control test versión argentina en sujetos con secuela de lesión medular espinaln secuela de lesión medular espinal

Revista del Hospital Italiano de Buenos Aires
Introducción: aquellas personas con buen control de tronco poseen una mayor probabilidad de realizar por sí mismas  actividades de la vida diaria independientemente del nivel de lesión y del grado de lesión; pero hasta el momento no contamos en la ...
Gerardo Candoni, Elizabeth Coronel, Marcos Valdez, Federico Scaminaci-Russo   +3 more
doaj   +1 more source