Results 111 to 120 of about 1,330,855 (256)

Lipoma intraóseo en fémur proximal. [PDF]

open access: yes, 2007
Se presenta un caso de una mujer de 74 años de edad con antecedente doloroso de la cadera izquierda de una año de evolución. En el estudio radiológico se aprecia una lesión quística en zona proximal del fémur del lado izquierdo asociada a signos de ...
Canillas del Rey, F.M.   +2 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

Los sentidos corporales, necesidad de actualizar su enfoque jurídico en Derecho Penal

open access: yesAnales
En el presente artículo se muestra la divergencia respecto de la consideración con la que médicos y abogados tratan los “sentidos corporales”. Esta divergencia ignora que la evolución del conocimiento científico es más veloz que la del jurídico.
Ricardo Germán Rincón   +1 more
doaj   +1 more source

¿Delito medioambiental como delito de lesión? [PDF]

open access: yes, 2010
El objetivo de este artículo es plantear cómo un estudio de la relación de ofensividad en los delitos contra el medio ambiente centrado en la figura del delito de peligro es insuficiente.
Fuentes Osorio, Juan Luis
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Lesión polipoidea colónica infrecuente [PDF]

open access: yes, 2008
Armas Padrón, José Ramón   +4 more
core   +1 more source

Enfermedad celíaca del adulto: vías de diagnóstico habituales [PDF]

open access: yes, 2016
Introducción: la enfermedad celíaca se ha considerado hasta hace unos años una enfermedad propia de la infancia. El diagnóstico en adultos es más complejo. Objetivos: 1. Analizar las distintas formas de presentación que tiene la EC en el adulto.
García Rivera, David
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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