Results 51 to 60 of about 1,086,495 (208)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Validez de constructo y utilidad clínica del Trunk control test versión argentina en sujetos con secuela de lesión medular espinaln secuela de lesión medular espinal

Revista del Hospital Italiano de Buenos Aires
Introducción: aquellas personas con buen control de tronco poseen una mayor probabilidad de realizar por sí mismas  actividades de la vida diaria independientemente del nivel de lesión y del grado de lesión; pero hasta el momento no contamos en la ...
Gerardo Candoni, Elizabeth Coronel, Marcos Valdez, Federico Scaminaci-Russo   +3 more
doaj   +1 more source

Reconstrucción de ligamento cruzado anterior de rodilla en mujeres deportistas

Revista Médica Clínica Las Condes, 2012
Actualmente ha habido un aumento en la práctica deportiva de la población femenina, fundamentalmente en deportes de contacto. Si comparamos con los hombres que practican el mismo deporte, las mujeres tienen hasta 8 veces mayor riesgo de rotura del LCA ...
Dr. M. Alejandro Orizola, C. Álvaro Zamorano   +1 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

La importancia del tratamiento inicial adecuado en una quemadura subdérmica en miembro inferior. Caso clínico

Gerokomos, 2018
RESUMEN La quemadura es una lesión térmica multicausal que afecta a diferentes tejidos corporales. En miembro inferior se complican con síndrome posflebítico, cicatrices retráctiles y disfunciones motoras, por lo que el diagnóstico precoz y el ...
Jordi Guinot-Bachero, Adrián García-Montero, Nuria Martínez-Blanco, Soledad Viedma-Contreras, Yolanda Gombau-Baldrich   +4 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Jurisprudencia medicolegal Vol. 9 Num. 92.

Estudios de Derecho, 1923
La colaboración de medicolegisla en la administración de justicia está acertadamente sintetizada en la siguiente doctrina, que es la norma medicolegal indiscutible: El médico ante los tribunales es más bien un juez que un perito.
Carlos A. Holguín
doaj