Human Cyclophilins—An Emerging Class of Drug Targets
Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova +3 more
wiley +1 more source
Pitfalls of Posterior Leads for Posterior Occlusion MI. [PDF]
Acad Emerg MedNewmarch T, El-Baba M, McLaren JTT.
europepmc +1 more source
RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source
Evaluating the Efficacy of AI-Assisted Quantitative Coronary Angiography in Reducing Procedural Time for Primary PCI in STEMI Patients: A Retrospective Analysis. [PDF]
J Korean Med SciAhn JH +11 more
europepmc +1 more source
NMR in Biomedicine, Volume 39, Issue 3, March 2026.Porcine livers underwent mechanical perfusion inside an MRI scanner, enabling dynamic quantitative measurements of whole organ perfusion. Vascular segmentation down to 0.45 mm resolution allowed quantification of morphological features such as vessel tortuosity, while Dynamic Contrast Enhanced MRI and diffusion weighted imaging was used to produce ...
Zainab L. Rai +9 more
wiley +1 more source
A human-scale porcine fasciocutaneous and muscle flap model for the evaluation of ortho-plastic reconstructions of lower-limb defects. [PDF]
J Bone Jt InfectSlater J +9 more
europepmc +1 more source
Cerebral in situ ischemic postconditioning: From bench to bedside and beyond
Neuroprotection, Volume 4, Issue 1, Page 48-64, March 2026.This review explores the translational potential of in situ ischemic postconditioning in acute ischemic stroke. Preclinical and clinical evidence is summarized to highlight its promise as a neuroprotective strategy in the era of endovascular therapy.
Xiao Jiang +4 more
wiley +1 more source
The value and limitations of the Oxford Community Stroke Project classification in the hyperacute phase of cerebral infarction. [PDF]
Front NeurolMiao Y, Li X, Wang S, Li C.
europepmc +1 more source
The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease
Prenatal Diagnosis, Volume 46, Issue 3, Page 368-381, March 2026.ABSTRACT Congenital heart disease (CHD) is the most frequent congenital malformation at birth and is associated with neurodevelopmental impairments. Alterations in cardiovascular physiology can lead to reduced cerebral blood perfusion and oxygenation, which negatively affects brain growth and maturation.
Maaike Nijman +7 more
wiley +1 more source
Correlation of Infarct Volume, Collateral Status, and Reperfusion with Clinical Outcome Following Mechanical Thrombectomy in Acute Ischemic Stroke. [PDF]
CureusCheekatla P +6 more
europepmc +1 more source