Results 101 to 110 of about 372,049 (317)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Utilidad de la ecografía con contraste en el diagnóstico de la obstrucción de la vía biliar [PDF]
, 2014 [Resumen] 1. Objetivo: Determinar el valor diagnóstico de la ecografía con contraste en la diferenciación entre lesiones benignas y malignas causantes de obstrucción de la vía biliar. 2.
Ríos Reboredo, Ángel
core +1 more source
QJM: An International Journal of Medicine, 2020 T, Gailson, S, Pandit, S, Rathi
openaire +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Seguridad ocupacional, uso de equipo de seguridad y prevención de lesiones musculares [PDF]
, 2016 El objetivo de esta monografía es descubrir si existe una relación entre las lesiones musculares y el uso del equipo de protección en los auxiliares de bodega.
Araujo Escobar, Carmen Irene +1 more
core
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Asociación entre lesión y calidad de vida en deportistas: [PDF]
, 2014 A pesar de los beneficios de participar en la vida deportiva, ello entraña una situación de riesgo debido a la ocurrencia de lesiones a cualquier nivel de desempeño. Dichas lesiones pueden afectar tanto a los aspectos físicos como psicológicos, y generar
Boneti Moreira, Natália +3 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source