Results 221 to 230 of about 107,994 (295)

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

[Development, techniques, and utility of experimental animal models of thoracic and abdominal aortic aneurysms]. [PDF]

Arch Cardiol Mex
Bravo-Reyna CC, Mejía-Cervantes J, Verduzco-Vázquez AT, Sánchez-Rodríguez C, Cuervo-Vargas L, Medina-Velázquez LA, Gómez-Vergara V, Hinojosa CA, Anaya-Ayala JE.   +8 more
europepmc   +1 more source

Serial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice

Advanced Science, EarlyView.
A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.
Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill   +12 more
wiley   +1 more source

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

Advanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong, Xingjin Li, Tao Hu, Qianqian Lu, Xiaoxu Zhang, Xi Chen, Yifan Luo, Zhong Zuo, Ronald Man Yeung Wong, Miao Xu, Tiancong Zhao, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Prevalence of skin injuries related to medical adhesives in Brazilian hospitals: a multicenter study. [PDF]

Rev Bras Enferm
Pio DF, Silva SPPD, Cortez DN, Moraes JT.   +3 more
europepmc   +1 more source

Developing a strategy for identifying recommendations prioritized for implementation in the Colombian health system. [PDF]

Health Res Policy Syst
Vélez M, Velásquez-Salazar P, Vera-Giraldo CY, Velásquez-Correa JC, Franco JS, Lugo-Agudelo LH, Vélez-Marín V, Fahim C, Marten R, Yangchen S, Straus S.   +10 more
europepmc   +1 more source

[Comparison of the epidemiological, clinical and diagnostic characteristics of infective endocarditis of native and prosthetic valves in a Peruvian reference center]. [PDF]

Arch Peru Cardiol Cir Cardiovasc
Espinoza-Alva D, Montesinos-Segura R, Mantilla-Huertas A, Davila-Flores D.   +3 more
europepmc   +1 more source

The obstetrician attached to the obstetric emergency. [PDF]

Colomb Med (Cali)
Villalobos Rodríguez AL.
europepmc   +1 more source