Results 181 to 190 of about 17,950,531 (342)

Effect of Flame Retardant (BDE-47) Exposure on Benthic Organisms from Coastal Areas: Experiment on Symbiont-Bearing Foraminifera of Genus <i>Peneroplis</i>. [PDF]

Toxics
Musco M, Di Natale MV, Torri M, Masullo T, Bennici CD, Cuttitta A.   +5 more
europepmc   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Seeing the similarities: Applying a coherent lens to harmful products as drivers of suicide. [PDF]

PLOS Glob Public Health
van Schalkwyk MCI, Knipe D, Cassidy R, Tyrell K, Collin J, Eddleston M.   +5 more
europepmc   +1 more source

Baseline Prostate-Specific Antigen Levels in Midlife Predict Lethal Prostate Cancer.

Journal of Clinical Oncology, 2016
M. Preston, Julie L. Batista, K. Wilson, S. Carlsson, T. Gerke, D. Sjoberg, D. Dahl, H. Sesso, A. Feldman, P. Gann, A. Kibel, A. Vickers, L. Mucci   +12 more
semanticscholar   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Limited 'heft' of weight-based outcomes in predicting influenza A virus disease severity in ferrets. [PDF]

PLoS Comput Biol
Kieran TJ, Maines TR, Belser JA.
europepmc   +1 more source

Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia.

Brain : a journal of neurology, 2016
Jijun Wan, Janos Steffen, Michael Yourshaw, H. Mamsa, Erik W Andersen, S. Rudnik-Schöneborn, K. Pope, K. Howell, C. Mclean, A. Kornberg, J. Joseph, P. Lockhart, K. Zerres, M. Ryan, S. Nelson, C. Koehler, J. Jen   +16 more
semanticscholar   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Response Surface Methodology-Based Optimization of Localized Heat Treatment for Managing <i>Cimex lectularius</i> (Hemiptera: Cimicidae) Infestations. [PDF]

Vet Med Int
Dejene F, Abera S, Jeyaramraja PR, Syraji Y.   +3 more
europepmc   +1 more source

LETHAL CONCENTRATION 50% (LC-50) EMPAT ISOLAT Edwardsiella tarda PADA IKAN AIR TAWARDI INDONESIA

, 2011
The aim of this study was to determine pathogenicity of Edwardsiella tarda isolates from different regions based on lethal concentration 50% (LC-50).
Perpustakaan UGM, i-lib
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