Results 211 to 220 of about 17,950,531 (342)

The RNA-binding activity of the <i>Drosophila</i> Brat protein is necessary for viability and mRNA regulation. [PDF]

RNA Biol
Connacher RP, Hu Y, Roden R, Toledo J, DesMarais A, O'Connor M, Lipshitz HD, Goldstrohm AC.   +7 more
europepmc   +1 more source

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

Trimeric hemagglutinin vaccine provides chickens complete protection against lethal H5 subtype avian influenza virus from clade 2.3.4.4b. [PDF]

Emerg Microbes Infect
Chen T, Huang Q, Chen X, Zhu J, Kong D, Liao X, Liao M, Fan H.   +7 more
europepmc   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Dose-Dependent Intestinal Transcriptomic and Metabolomic Responses to Acute Waterborne Glyphosate Exposure in the Sea Cucumber (<i>Apostichopus japonicus</i>). [PDF]

Biology (Basel)
Sun J, Zhang L, Hepburn CD, Kuang S, Yang H.   +4 more
europepmc   +1 more source

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

Advanced Science, EarlyView.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang, Bin Li, Zhijin Fan, Yan Yan, Fei Ma, Changting He, Shiping Liu, Mingliang Pan, Zhou Pan, Huijuan Wang, Xinting Fu, Jiamei Wang, Yue Jia, Qin Gu, Duo Jiang, Xueting Liu, Bohua Ren, Qinqin Wang, Yuehua Hei, Han Duan, Yanqiu Wu, Zihui Wei, Liying Zhan, Yuhui Liao   +23 more
wiley   +1 more source

Sublethal Abamectin as a Population Suppressant: Decoding the Transgenerational Impact on the Asian Citrus Psyllid for Sustainable Management. [PDF]

Biology (Basel)
Han Q, Xiang M, Yuan Z, Liu H, Gong B, Yang Z.   +5 more
europepmc   +1 more source

Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma

Cancer Research, 2004
R. Galli, Elena Binda, U. Orfanelli, B. Cipelletti, A. Gritti, Simona De Vitis, R. Fiocco, C. Foroni, F. DiMeco, A. Vescovi   +9 more
semanticscholar   +1 more source

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

A Gene Expression Tumor Signature Optimizing Partial Area-Under-the-Curve (pAUC) to Improve Specificity for Indolent Prostate Cancer. [PDF]

Prostate
Gerke TA, Tyekucheva S, Stopsack KH, Sweeney CJ, Lis RT, Westling EN, Loda M, Stampfer MJ, Penney KL, Parmigiani G, Mucci LA.   +10 more
europepmc   +1 more source