Results 261 to 270 of about 17,950,531 (342)

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

A non-lethal method for the sampling of the gut microbiota in <i>Betta splendens</i>. [PDF]

Front Vet Sci
Pun KI, Jinatham V, Saidu MB, Sapage M, Popluechai S, Antunes A, Saninjuk K, Gonçalves D.   +7 more
europepmc   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Proteome-wide prediction of the functional impact of missense variants with ProteoCast. [PDF]

Nat Commun
Abakarova M, Freiberger MI, Liehrmann A, Rera M, Laine E.   +4 more
europepmc   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

Prostate Cancer Index Density, the Ratio of Percentage of Biopsy-Positive Cores to Prostate Volume, and Predicted Lethal Disease in the EAU Intermediate Prognostic Risk Class: Analysis and Implications in 651 Consecutive Patients Treated with Robot-Assisted Radical Prostatectomy at a Tertiary Referral Centre. [PDF]

Cancers (Basel)
Porcaro AB, Cerruto MA, Bianchi A, Bertolo RG, Artoni F, Baielli A, Franceschini A, Montanaro F, Costantino S, Veccia A, Rizzetto R, Brunelli M, Siracusano S, Antonelli A.   +13 more
europepmc   +1 more source

Effects of Temperature and Exposure Duration on Energy Substances and Antioxidant Enzymes in <i>Riptortus pedestris</i> (Hemiptera: Alydidae). [PDF]

Insects
Song K, Zhang L, Li X, Zhao S, Qu W, Xu ML, Yang J, Gao Y.   +7 more
europepmc   +1 more source

Internalized Evolutionary Inertia on Body Plan Evolution. [PDF]

Evol Dev
Zeng W, Irie N.
europepmc   +1 more source

Unbiased CRISPR synthetic lethal screening for genetic vulnerabilities in a succinate dehydrogenase-loss model of paraganglioma. [PDF]

iScience
Al Khazal FJ, Emch MJ, Correia C, Favier J, Hawse JR, Maher LJ.   +5 more
europepmc   +1 more source

A single residue in the VP3 capsid protein governs virulence and informs live-attenuated vaccine design for coxsackievirus A6. [PDF]

J Virol
Liu K, Liu Z, Yan X, Yang Z, Li X, Zhang C.   +5 more
europepmc   +1 more source