Results 11 to 20 of about 202,850 (314)

Synthetic Lethality Targeting Polθ [PDF]

, 2022
Research studies regarding synthetic lethality (SL) in human cells are primarily motivated by the potential of this phenomenon to be an effective, but at the same time, safe to the patient’s anti-cancer chemotherapy.
Gabriela Barszczewska-Pietraszek, Tomasz Skorski, Drzewiecka, Małgorzata, Skorski, Tomasz, Czarny, Piotr, Barszczewska-Pietraszek, Gabriela, Małgorzata Drzewiecka, Tomasz Śliwiński, Śliwiński, Tomasz, Piotr Czarny   +9 more
core   +1 more source

Anti-angiogenesis therapy, synthetic lethality, and checkpoint inhibition in ovarian cancer: state of the science and novel combinations [PDF]

, 2018
Over the last decade, new therapeutics in the form of anti-angiogenic treatment, synthetic lethality, and checkpoint inhibition have offered new options for the treatment of ovarian cancer.
Krishnansu S Tewari, Liu, Marisa C, Tewari, Krishnansu S, Marisa C Liu   +3 more
core   +1 more source

Potential Lethality of Suicide Attempts in Youth

, 2021
Objective: Rates of suicide in youth have increased over the last 50 years, yet our ability to predict suicidal behaviors has not significantly improved during this time.
Jopling, Ellen, Kerns, Connor M., Eslami, Ali, Nugent, S., LeMoult, Joelle   +4 more
core   +1 more source

Determination of in vivo toxicity and in vitro cytotoxicity of venom from the Cypriot blunt-nosed viper Macrovipera lebetina lebetina and antivenom production

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
The venomous Levantine viper, Macrovipera lebetina lebetina is endemic to Cyprus. The objective of this study was to investigate in vitro cytotoxicity, in vivo lethality, and antivenom production followed by a re-immunization schedule in mice against ...
A Nalbantsoy, NU Karabay-Yavasoglu, F Sayim, I Deliloglu-Gurhan, B Gocmen, H Arikan, MZ Yildiz   +6 more
doaj   +1 more source

Hematocytological, biochemical, and hemostasis parameters' role in predicting the possibility of the various forms of the COVID‐19 course in hospitalized Ukrainian patients: A cross‐sectional study

Health Science Reports, 2023
Background and Aims The main objective of this study is to establish the characteristics of blood laboratory parameters in hospitalized coronavirus disease 2019 (COVID‐19) Ukrainian patients and the significance of the above‐mentioned parameters for ...
Anna Yushchuk, Vasyl Pykaliuk, Olha Korzhyk   +2 more
doaj   +1 more source

The dynamics of lethality by the progression of the pulmonary tuberculosis process of the new cases patients

One Health & Risk Management, 2023
Introduction. Mortality among tuberculosis patients, both nationally and globally, has decreased significantly in the last 10 years, but the current epidemiological situation in tuberculosis allows to predict a new rise in the endemic state of the ...
Aurelia USTIAN, Alina MALIС, Constantin IAVORSCHI, Stela KULCITKAIA, Tatiana OSIPOV, Igor IVANES   +5 more
doaj   +1 more source

Noncompact Myocardium with Dilated Phenotype: Manifestations, Treatment and Outcomes in Comparison with Other Forms of Dilated Cardiomyopathy Syndrome

Рациональная фармакотерапия в кардиологии, 2022
Aim. To study the place of NCM in the structure of DCM, its clinical features and influence on prognosis in comparison with other forms of DCM syndrome.Methods. The NCM registry includes 125 patients, mean age 46.4±15.1 years, 74 men and 51 women, median
O. V. Blagova, E. V. Pavlenko, N. V. Varionchik, V. P. Sedov, N. V. Gagarina, E. A. Mershina, M. E. Polyak, E. V. Zaklyazminskaya, A. V. Nedostup   +8 more
doaj   +1 more source

Refined Analysis of the Correlation Between the Accepted Maximum Permissible Levels of Radio Frequency Electromagnetic Fields for the Population and the Lethality Rate of Covid-19

Доклады Белорусского государственного университета информатики и радиоэлектроники, 2022
In this paper, the results of a refined analysis of the correlation, previously discovered by the author, between the accepted maximum permissible levels (MPL) of radio frequency electromagnetic fields (RF EMF) for population and the mortality rate of ...
V. I. Mordachev
doaj   +1 more source

Lethal Bubbles [PDF]

Indian Journal of Surgery, 2013
The present paper reports the case of a hyperacute gaseous gangrene diffuse to the whole body.
Coccolini F., Arzu G. D., Manfredi R., Monteverdi F., Maggioni D., Ansaloni L.   +5 more
openaire   +3 more sources

Therapeutic and Prognostic Implications of Immune-Related Adverse Events in Advanced Non-Small-Cell Lung Cancer

Frontiers in Oncology, 2021
IntroductionPD-(L)1 inhibitors have improved prognosis of non-small-cell lung cancer (NSCLC), but can also cause immune-related adverse events (irAEs) that complicate management.MethodsWe analyzed NSCLC patients receiving PD-(L)1 inhibitors from 2012 to ...
Lea Daniello, Lea Daniello, Mariam Elshiaty, Mariam Elshiaty, Farastuk Bozorgmehr, Farastuk Bozorgmehr, Jonas Kuon, Jonas Kuon, Daniel Kazdal, Daniel Kazdal, Hannah Schindler, Hannah Schindler, Rajiv Shah, Rajiv Shah, Anna-Lena Volckmar, Fabienne Lusky, Fabienne Lusky, Leonore Diekmann, Stephan Liersch, Martin Faehling, Thomas Muley, Thomas Muley, Mark Kriegsmann, Mark Kriegsmann, Karolina Benesova, Albrecht Stenzinger, Albrecht Stenzinger, Michael Thomas, Michael Thomas, Petros Christopoulos, Petros Christopoulos   +30 more
doaj   +1 more source