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Collateral lethality: A unique type of synthetic lethality in cancers
Pharmacology & TherapeuticsGenetic interactions play crucial roles in cell-essential functions. Intrinsic genetic defects in tumors typically involve gain-of- and loss-of-function mutations in tumor suppressor genes (TSGs) and oncogenes, respectively, providing potential antitumor vulnerabilities.
Zichen, Zhao +4 more
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Synthetic lethality-mediated precision oncology via the tumor transcriptome
Cell, 2021Joo Sang Lee +2 more
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Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines
Cell Systems, 2021Barbara De Kegel +2 more
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Capitalizing on Synthetic Lethality of MYC to Treat Cancer in the Digital Age
Trends in Pharmacological Sciences, 2021Dexter Kai Hao Thng +2 more
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Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy
Acta Pharmaceutica Sinica B, 2021Jieqiong You, Wen Meng, Qiaojun He
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