Results 91 to 100 of about 314,296 (164)

CREAT: A CRISPR‐Based Genome Trimming Strategy for Systematic Identification of Dispensable Regions and Rapid Genome Reduction

Advanced Science, EarlyView.
Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan, Zhe Gao, Yingxuan Qi, Yang Zhang, Xuhui Tian, Pengpeng Zhao, Xu Feng, Qunxin She   +7 more
wiley   +1 more source

Synergistic Integration of Artificial Merkel Disc and Meissner Corpuscle via Dermal Papillary Structures for Mechanically Filtered Multimodal Tactile Sensing

Advanced Science, EarlyView.
A multimodal tactile sensor module that mimics the spatial arrangement and function of Merkel discs and Meissner corpuscles within the human papillary structure operates in a self‐powered manner, responding to both dynamic and static stimuli, achieving tactile perception more similar to human skin.
Jaehyeong Kim, Bohee Maeng, Seunghwan Seo, Kyoung‐Yong Chun, Chang‐Soo Han   +4 more
wiley   +1 more source

Synergistic Effect of Gradient Conductivity and Gradient Microstructures Enabled Ultrasensitive and Ultrabroad Linear Flexible Tactile Sensors

Advanced Science, EarlyView.
A design of double gradient effect is proposed to resolve the contradictory optimization on sensitivity and linearity of piezoresistive tactile sensors. The ultrawide linearity is realized by the sequential trigger of pressure‐induced gradient conductivity‐enabled linear current owing to the gradient microstructures.
Yao Fang, Yiwei Wang, Bing Zheng, Liu Yang, Jingyi Yue, Qian Zhou, Jinrong Huang, Yongyun Mao, Qian Li, Jifei Wang, Dongsheng Tang, Yuxin Tang, Bingpu Zhou, Bing Ji   +13 more
wiley   +1 more source

Closed‐Loop Decoding and Intervention of Pain: A Novel BMI Strategy Integrating θ‐Band Detection and Mechano‐Electro‐Biological Coupled Hydrogels

Advanced Science, EarlyView.
A closed‐loop brain–machine interface with a PFAPT hydrogel electrode identifies prefrontal θ‐band as a neuropathic pain biomarker. The hydrogel enables stable 28 d ECoG recording and delivers θ‐triggered cortical stimulation, alleviating pain and affective behaviors in rats via bidirectional regulation of inflammation and central sensitization ...
Yun Ji, Tao Li, Guoqiang Lei, Huichun Luo, Xiuqian Guo, Jiao Xiang, Tao Shi, Weitang Liu, Yuxin Zhang, Xiaoyu Liao, Shutao Zhao, Jiayun Wu, Wangao Zhang, Wenhui Liu, Chuanglong He, Shuo Chen, Tao Wu, Ke Ma   +17 more
wiley   +1 more source

A Portable Soft Robotic Glove with Fully Functional Thumb Assistance for Complex Dexterous Fine Motor Skills

Advanced Science, EarlyView.
A portable, sensorized, and controlled dexterous thumb‐enhanced glove helps stroke survivors swipe phones, twist caps, and perform other tasks. It is based on a powerful continuously, segmented origami dual chamber actuator to achieve active thumb CMC and MCP joint assistance and passively extend the IP joint.
Disheng Xie, Zhen Wang, Zhongping Ye, Minghao Liu, Xiangqian Shi, Shuk Fan Tong, Jianbin Liu, Chuanbin Mao, Thomas W. Leung, Haitao Liu, Raymond Kai‐yu Tong   +10 more
wiley   +1 more source

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source

Oxygen Vacancy‐Mediated Bi─O Unsaturation Coordination in BiOCl for Efficient Photocatalytic Water Purification

Advanced Science, EarlyView.
The incorporation of oxygen vacancies (OVs) presents a viable strategy for fine‐tuning the photocatalytic prowess of BiOCl. A reliable hydrogen annealing reduction technique is employed to precisely design OVs, thereby optimizing the light absorption capacity, as well as the efficiency of carrier migration and separation in BiOCl.
Shuaihao Ma, Jianglong Kong, Shidong Zhang, Wentao Li, Ling Yan, Deng Long, Xinglin Yu, Dawei Wang, Zheng Han, Sihan Ma, Lin Wang, Guang Ran   +11 more
wiley   +1 more source

Letter from the Editor

Singapore Dental Journal, 2013
openaire   +4 more sources

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

A Multimodal Haptic Feedback Interface with Thin‐Film Compliant Mechanism

Advanced Science, EarlyView.
Multimodal haptic devices can trigger different mechanoreceptors, enabling richer haptic information. This study presents an electromagnetic multimodal haptic device capable of delivering indentation, stretch, and vibration stimuli. The device is enabled by a novel polymer thin‐film compliant mechanism that provides high translational compliance along ...
Jingjing Wan, Emanuele Nicotra, James Davies, Kefan Zhu, Quang Anh Nguyen, Sinuo Zhao, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Hermione Truong, Patrick Pruscino, Tan Huynh, Phuoc Thien Phan, Hoang‐Phuong Phan, Nigel Hamilton Lovell, Thanh Nho Do   +15 more
wiley   +1 more source