Advanced Science, EarlyView.Cryo‐EM analysis reveals an asymmetric MMOH–MMOB complex with distinct protomers, where MMOB binding triggers structural rearrangements from the surface to the active site. This conformational asymmetry shortens the Fe···Fe distance to 2.7 Å in one protomer, forming a geometry suitable for O2 activation and supporting a sequential catalytic mechanism ...
Yunha Hwang +9 more
wiley +1 more source
A Serious Challenge In Innovation Program Of Medical Education: Need Assessment Of Medical Sciences Disciplines In Iran [PDF]
مجله ایرانی آموزش در علوم پزشکی, 2018 Esmaeil Akbari
doaj
Response to Letter to Editor-The Quality of Health Towards Resilience Community in Indonesia: A Resilience Policy Discourse. [PDF]
Health Sci RepBegum A, Uddin MA.
europepmc +1 more source
His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models
Advanced Science, EarlyView.His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li +13 more
wiley +1 more source
Response to the Letter to Editor regarding: "High effectiveness of multilevel orthopedic surgery and guided growth in spastic hemiplegia children". [PDF]
J Child OrthopMamedov U +5 more
europepmc +1 more source
Genetic Diagnosis and Discovery Enabled by Large Language Models
Advanced Science, EarlyView.We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu +25 more
wiley +1 more source
Critical insight on 'respiratory swallow coordination training using bimodal signal biofeedback for patients with post-stroke dysphagia: a letter to editor. [PDF]
Ann MedKumar P, Kanika.
europepmc +1 more source
Advanced Science, EarlyView.This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong +7 more
wiley +1 more source
Letter to Editor regarding 'Variants in the interferon regulatory factor 5 gene confer genetic risk for systemic lupus erythematosus in a Han Chinese population'. [PDF]
Ann MedPanda AK, Sharma S.
europepmc +1 more source