Results 61 to 70 of about 689,537 (284)

Telomere protein complexes and their role in lymphoid malignancies [PDF]

, 2017
Telomeres are highly regulated and dynamic complexes that protect the genomic DNA and prevent the end of linear chromosomes from being misrecognized as a broken DNA.
Dos Santos, Patricia Carolina, Panero, Julieta, Slavutsky, Irma Rosa   +2 more
core  

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. [PDF]

, 2014
In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly understood, as AML is typically diagnosed without observation of a pre-leukaemic phase.
Brandwein, Joseph M, Brown, Andrew MK, Chen, Weihsu Claire, Dick, John E, Doedens, Monica, Gupta, Vikas, HALT Pan-Leukemia Gene Panel Consortium, Hudson, Thomas J, Kennedy, James A, Kim, Hyeoung Joon, Lee, Kwon, Marke, Rene, McLeod, Jessica L, McPherson, John D, Medeiros, Jessie JF, Minden, Mark D, Mitchell, Amanda, Schimmer, Aaron D, Schuh, Andre C, Shlush, Liran I, Stein, Lincoln D, Trinh, Quang M, Wang, Jean CY, Yee, Karen W, Yousif, Fouad, Zandi, Sasan   +25 more
core   +2 more sources

Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis

Cell Journal, 2017
Epigenetic and genetic alterations are two mechanisms participating in leukemia, which can inactivate genes involved in leukemia pathogenesis or progression.
Nazanin Heidari , Saeid Abroun, Jessika Bertacchini, Tina Vosoughi, Fakher Rahim, Najmaldin Saki   +5 more
doaj   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Characterization of the monocyte-specific esterase (MSE) gene [PDF]

, 1994
Carboxylic esterases are widely distributed in hematopoietic cells. Monocytes express the esterase isoenzyme (termed 'monocyte-specific esterase', MSE) that can be inhibited by NaF in the alpha-naphthyl acetate cytochemical staining.
Drexler, H. G., Gignac, S. M., Hu, Z. B., Kreutz, Marina, Ludwig, W. D., Ma, W., Rainey, F. A., Uphoff, C. C.   +7 more
core  

Elevated myc expression and c-myc amplification in spontaneously occurring B lymphoid cell lines [PDF]

, 1987
Recently, a minor subpopulation of murine B lymphocytes, Ly-1+ B cells, has been distinguished by its unique ontogeny, tissue distribution, and prominence in certain autoimmune and neoplastic B cell diseases.
Baltimore, David, Braun, Jonathan, Citri, Yoav   +2 more
core   +1 more source

A rare presentation of chronic myeloid leukemia blast crisis

Iraqi Journal of Hematology, 2020
Chronic myeloid leukemia (CML), as the name suggests, is a chronic disorder in which granulocytes undergo dysregulated production and uncontrolled proliferation. Majority of CML patients present during the chronic phase (CP) of the disease.
P S Shruthi, Sunil Prabhakar Udgire, Raseed Imamsab Munawalli, Sakthivel Murugan   +3 more
doaj   +1 more source

Spectrum and trigger identification of hemophagocytic lymphohistiocytosis in adults: A single-center analysis of 555 cases

Frontiers in Immunology, 2022
Limited data are available about the underlying causes of hemophagocytic lymphohistiocytosis (HLH) in adults. We collected and analyzed the data of 555 cases of adult HLH.
Yi Miao, Yi Miao, Yi Miao, Jing Zhang, Jing Zhang, Jing Zhang, Qingqing Chen, Qingqing Chen, Qingqing Chen, Lingxiao Xing, Lingxiao Xing, Lingxiao Xing, Tonglu Qiu, Tonglu Qiu, Tonglu Qiu, Huayuan Zhu, Huayuan Zhu, Huayuan Zhu, Li Wang, Li Wang, Li Wang, Lei Fan, Lei Fan, Lei Fan, Wei Xu, Wei Xu, Wei Xu, Jianyong Li, Jianyong Li, Jianyong Li, Jianyong Li   +30 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Protein stabilization explains the gag requirement for transformation of lymphoid cells by Abelson murine leukemia virus [PDF]

, 1985
The single protein encoded by Abelson murine leukemia virus is a fusion of sequence from the retroviral gag genes with the v-abl sequence. Deletion of most of the gag region from the transforming protein results in a virus capable of transforming ...
Baltimore, David, Hoag, Jennifer, Prywes, Ron, Rosenberg, Naomi   +3 more
core