Results 111 to 120 of about 541,695 (230)

Age and acute myeloid leukemia

Blood, 2006
We conducted a retrospective analysis of 968 adults with acute myeloid leukemia (AML) on 5 recent Southwest Oncology Group trials to understand how the nature of AML changes with age. Older study patients with AML presented with poorer performance status, lower white blood cell counts, and a lower percentage of marrow blasts.
Marilyn L. Slovak, Jeanne E. Anderson, Cheryl L. Willman, Frederick R. Appelbaum, Stephen H. Petersdorf, David R. Head, Holly Gundacker, John E. Godwin   +7 more
openaire   +3 more sources

Granulocytic Sarcoma as the First Sign of Acute Leukemia in Childhood [PDF]

, 2012
Acute myeloid leukemia (AML) may rarely involve the orbit as a solid tumor termed granulocytic sarcoma. This report describes the case of a child who presented with rapidly progressive unilateral proptosis and was diagnosed as rhabdomyosarcoma.
Singh, T, Sufi, AR
core   +1 more source

Radotinib inhibits mitosis entry in acute myeloid leukemia cells via suppression of Aurora kinase A expression

Tumor Biology, 2019
Aurora kinases play critical roles in regulating several processes pivotal for mitosis. Radotinib, which is approved in South Korea as a second-line treatment for chronic myeloid leukemia, inhibits the tyrosine kinase BCR-ABL and platelet-derived growth ...
Sook-Kyoung Heo, Eui-Kyu Noh, Yoo Kyung Jeong, Lan Jeong Ju, Jun Young Sung, Ho-Min Yu, Jaekyung Cheon, SuJin Koh, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo   +10 more
doaj   +1 more source

Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations

Haematologica, 2016
In recent years, it has been reported that the frequency of DNA-methylation regulatory gene mutations – mutations of the genes that regulate gene expression through DNA methylation – is high in acute myeloid leukemia.
Takeshi Ryotokuji, Hiroki Yamaguchi, Toshimitsu Ueki, Kensuke Usuki, Saiko Kurosawa, Yutaka Kobayashi, Eri Kawata, Kenji Tajika, Seiji Gomi, Junya Kanda, Anna Kobayashi, Ikuko Omori, Atsushi Marumo, Yusuke Fujiwara, Shunsuke Yui, Kazuki Terada, Keiko Fukunaga, Tsuneaki Hirakawa, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Hayato Tamai, Kazutaka Nakayama, Satoshi Wakita, Takahiro Fukuda, Koiti Inokuchi   +25 more
doaj   +1 more source

Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells

Haematologica, 2018
Patient-derived xenotransplantation models of human myeloid diseases including acute myeloid leukemia, myelodysplastic syndromes and myeloproliferative neoplasms are essential for studying the biology of the diseases in pre-clinical studies. However, few
Maria Krevvata, Xiaochuan Shan, Chenghui Zhou, Cedric Dos Santos, Georges Habineza Ndikuyeze, Anthony Secreto, Joshua Glover, Winifred Trotman, Gisela Brake-Silla, Selene Nunez-Cruz, Gerald Wertheim, Hyun-Jeong Ra, Elizabeth Griffiths, Charalampos Papachristou, Gwenn Danet-Desnoyers, Martin Carroll   +15 more
doaj   +1 more source

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Nature Communications, 2018
Mcl-1 is a member of the Bcl-2 family of proteins that promotes cell survival by preventing induction of apoptosis in many cancers. High expression of Mcl-1 causes tumorigenesis and resistance to anticancer therapies highlighting the potential of Mcl-1 ...
A. Tron, M. Belmonte, Ammar Adam, Brian Aquila, Brian Aquila, L. Boise, E. Chiarparin, Justin Cidado, K. Embrey, E. Gangl, F. Gibbons, G. Gregory, G. Gregory, D. Hargreaves, J. A. Hendricks, J. Johannes, R. Johnstone, R. Johnstone, S. Kazmirski, J. Kettle, L. Michelle, Shannon M Matulis, A. Nooka, M. Packer, Bo Peng, P. Rawlins, Daniel W. Robbins, A. Schuller, Nancy Su, Wenzhan Yang, Q. Ye, Xiaolan Zheng, J. Secrist, E. Clark, David M. Wilson, S. Fawell, A. Hird   +36 more
semanticscholar   +1 more source

Acute Myeloid Leukemia Associated Leukocytic Hypophysitis Presenting with Central Diabetes Insipidus

AACE Clinical Case Reports, 2018
: Objective: Central diabetes insipidus is a rare complication of acute myeloid leukemia and myelodysplastic syndrome. To date there are fewer than 100 cases reported in the literature, and no published case reports in the endocrinology literature.
Joshua A. Levine, MD, PhD, Ashley Pariser, MD, Eve Bloomgarden, MD   +2 more
doaj   +1 more source

Chidamide and cytarabine synergistically treat acute myeloid leukemia: inhibiting ribosome biogenesis via the MYC-RRP9 pathway

Cell Death and Disease
This study explores innovative therapeutic approaches for acute myeloid leukemia by examining the synergistic effects of the histone deacetylase inhibitor chidamide in combination with cytarabine. In both in vitro and in vivo models, the drug combination
Qing Li, Fangfang Wang, Xinrong Xiang, Lei Zhao, Xuefeng Li, Ying Qu, Jingcao Huang, Yunfan Yang, Yang Dai, Xiao Shuai, Jiazhuo Liu, Jie Huang, Yu Liu, Yu Wu   +13 more
doaj   +1 more source

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

Haematologica, 2008
Background Aurora kinases play an essential role in the orchestration of chromosome separation and cytokinesis during mitosis. Small-molecule inhibition of the aurora kinases has been shown to result in inhibition of cell division, phosphorylation of ...
Elisabeth Walsby, Val Walsh, Chris Pepper, Alan Burnett, Ken Mills   +4 more
doaj   +1 more source

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.

Blood, 2016
D. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. Borowitz, M. L. Le Beau, C. Bloomfield, M. Cazzola, J. Vardiman   +8 more
semanticscholar   +1 more source