Results 221 to 230 of about 305,001 (288)

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Cutaneous and Orbital Myeloid Sarcoma as the Initial Clinical Presentation of Acute Myeloid Leukemia in an Infant. [PDF]

Dermatol Pract Concept
Di Carlo Del Vecchio L, Lapins J, Fernandes EL, de Alvarenga Lira ML, Magalhães F, Moleta M.   +5 more
europepmc   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Pleural Infiltration Revealing Post-Essential Thrombocythemia Acute Myeloid Leukaemia. [PDF]

EJHaem
Muron C, Luque Paz D, Copin MC, Orvain C.   +3 more
europepmc   +1 more source

Plasma levels of Human Granulocytic Elastase-alpha-Proteinase Inhibitor Complex (E-alpha1PI) in Leukemia [PDF]

, 1984
Hiller, E., Jochum, Marianne
core  

Comparative Analysis of Isavuconazole DDIs With Other Azole Antifungal Drugs and PBPK Model‐Informed Dosing Recommendations for Anticancer Drugs

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Isavuconazole is a broad‐spectrum triazole approved for the treatment of invasive aspergillosis or mucormycosis in adults and children aged ≥ 1 year. Current prescribing information lacks guidance regarding the co‐administration of isavuconazole with anticancer drugs–limited by the availability of clinical drug–drug interaction (DDI) data in ...
Theunis C. Goosen, Xiaofeng Wu, Jian Lin, Narayan Cheruvu, Susan R. Raber, Maria Lavinea Novis de Figueiredo, Manthena V. S. Varma   +6 more
wiley   +1 more source

Low survival in younger adults with Acute Myeloid Leukemia (AML) in Tanzania linked to high disease burden and socioeconomic factors. [PDF]

PLoS One
Munroe M, Chamba C, Yonazi M, Mahfudh S, Mawalla W, Mbelekwa K, Kaaya G, Mwakichako R, Mshiu J, Lyimo M, Ally M, Nasser A.   +11 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Aggressive Disease and Poor Clinical Outcome in CEBPα-Mutated Acute Myeloid Leukemia Patient. [PDF]

Clin Case Rep
Alshammari AA, AlSabbagh MO, Alshehri HM, AlSwayyed AF, Alseraye FM, Peer-Zada AA.   +5 more
europepmc   +1 more source

Andrias Davidianus Peptide Hydrogel Enables Sustained SR9011 Release to Promote Efferocytosis and Alleviate Colitis

Small, EarlyView.
NR1D1 suppresses epithelial CD47 transcription to promote efferocytosis by macrophages. In UC, NR1D1 expression is diminished, leading to CD47 upregulation, inhibition of apoptotic cell clearance, and exacerbation of intestinal inflammation. Restoring rhythmic NR1D1 activation using SR9011‐loaded bioadhesive hydrogel enhances efferocytosis, improves ...
Yidong Chen, Jiamin Li, Junrong Li, Xiaopeng Zhang, Fang Liu, Qi Yu, Rong Lin, Liangru Zhu   +7 more
wiley   +1 more source