Results 81 to 90 of about 1,795,288 (205)

Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner

Haematologica, 2016
The growth of malignant cells is not only driven by cell-intrinsic factors, but also by the surrounding stroma. Monocytes/Macrophages play an important role in the onset and progression of solid cancers.
Yahya S. Al-Matary, Lacramioara Botezatu, Bertram Opalka, Judith M. Hönes, Robert F. Lams, Aniththa Thivakaran, Judith Schütte, Renata Köster, Klaus Lennartz, Thomas Schroeder, Rainer Haas, Ulrich Dührsen, Cyrus Khandanpour   +12 more
doaj   +1 more source

A novel self-lipid antigen targets human T cells against CD1c(+) leukemias [PDF]

, 2014
T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects.
Lepore, Marco, Locatelli, Franco, Giulia Casorati, Paul Jenö, Chengfeng Xia, Consonni, Michela, S. R. Gundimeda, P. Jeno, Daniela Montagna, C. Bonini, Alessandra Forcina, G. Casorati, Claudia de Lalla, Franco Locatelli, Sansano, Sebastiano, Bonini, Chiara, Piccolo, Francesco, Xia, Chengfeng, Z. Li, P. Dellabona, Garavaglia, Claudio, H. Gsellinger, F. Piccolo, de Lalla, Claudia, Paolo Dellabona, G. Ni, F. Ciceri, Gundimeda, S. Ramanjaneyulu, Heiko Gsellinger, Häussinger, Daniel, Daniel Häussinger, Scelfo, Andrea, L. Mori, C. Garavaglia, Gennaro De Libero, A. Bondanza, Michela Consonni, Sebastiano Sansano, A. Forcina, Ciceri, Fabio, Jenö, Paul, Fabio Ciceri, M. Lepore, Attilio Bondanza, Gsellinger, Heiko, De Libero, Gennaro, S. Sansano, Bondanza, Attilio, Casorati, Giulia, D. Haussinger, Marco Lepore, C. de Lalla, G. De Libero, M. Consonni, Guanghui Ni, Lucia Mori, Li, Zhiyuan, Zhiyuan Li, Montagna, Daniela, Forcina, Alessandra, Andrea Scelfo, Mori, Lucia, S. Ramanjaneyulu Gundimeda, Chiara Bonini, Claudio Garavaglia, A. Scelfo, Francesco Piccolo, Ni, Guanghui, C. Xia, Dellabona, Paolo   +69 more
core   +1 more source

Radotinib inhibits mitosis entry in acute myeloid leukemia cells via suppression of Aurora kinase A expression

Tumor Biology, 2019
Aurora kinases play critical roles in regulating several processes pivotal for mitosis. Radotinib, which is approved in South Korea as a second-line treatment for chronic myeloid leukemia, inhibits the tyrosine kinase BCR-ABL and platelet-derived growth ...
Sook-Kyoung Heo, Eui-Kyu Noh, Yoo Kyung Jeong, Lan Jeong Ju, Jun Young Sung, Ho-Min Yu, Jaekyung Cheon, SuJin Koh, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo   +10 more
doaj   +1 more source

Investigations of FLT3 internal tandem duplications in patients with acute myeloid leukaemia. [PDF]

, 2006
In acute myeloid leukaemia (AML), further prognostic determinants are required in addition to cytogenetics to predict patients at increased risk of relapse. Recent studies have indicated an internal tandem duplication (ITD) in the FLT3 gene may adversely
Kottaridis, P.D., Kottaridis, Panagiotis
core  

Clinical and molecular characterization of early T-cell precursor leukemia : a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations [PDF]

, 2012
A subgroup of pediatric acute T-lymphoblastic leukemia (T-ALL) was characterized by a gene expression profile comparable to that of early T-cell precursors (ETPs) with a highly unfavorable outcome.
Hoelzer, Dieter, Farhadi-Sartangi, Nasrin, Schlee, Cornelia, Hofmann, Wolf-Karsten, Thiel, Eckhard, Burmeister, Thomas, Neumann, Martin, Thibaut, Julia, Gökbuget, Nicola, Heesch, Sandra, Schwartz, Stefan, Benlasfer, Ouidad, Baldus, Claudia   +12 more
core   +1 more source

Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations

Haematologica, 2016
In recent years, it has been reported that the frequency of DNA-methylation regulatory gene mutations – mutations of the genes that regulate gene expression through DNA methylation – is high in acute myeloid leukemia.
Takeshi Ryotokuji, Hiroki Yamaguchi, Toshimitsu Ueki, Kensuke Usuki, Saiko Kurosawa, Yutaka Kobayashi, Eri Kawata, Kenji Tajika, Seiji Gomi, Junya Kanda, Anna Kobayashi, Ikuko Omori, Atsushi Marumo, Yusuke Fujiwara, Shunsuke Yui, Kazuki Terada, Keiko Fukunaga, Tsuneaki Hirakawa, Kunihito Arai, Tomoaki Kitano, Fumiko Kosaka, Hayato Tamai, Kazutaka Nakayama, Satoshi Wakita, Takahiro Fukuda, Koiti Inokuchi   +25 more
doaj   +1 more source

Acute Myeloid Leukemia [PDF]

Journal of the National Comprehensive Cancer Network, 2011
Margaret R, O'Donnell, Camille N, Abboud, Jessica, Altman, Frederick R, Appelbaum, Steven E, Coutre, Lloyd E, Damon, James M, Foran, Salil, Goorha, Lori J, Maness, Guido, Marcucci, Peter, Maslak, Michael M, Millenson, Joseph O, Moore, Farhad, Ravandi, Paul J, Shami, B Douglas, Smith, Richard M, Stone, Stephen A, Strickland, Martin S, Tallman, Eunice S, Wang   +19 more
openaire   +2 more sources

Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells

Haematologica, 2018
Patient-derived xenotransplantation models of human myeloid diseases including acute myeloid leukemia, myelodysplastic syndromes and myeloproliferative neoplasms are essential for studying the biology of the diseases in pre-clinical studies. However, few
Maria Krevvata, Xiaochuan Shan, Chenghui Zhou, Cedric Dos Santos, Georges Habineza Ndikuyeze, Anthony Secreto, Joshua Glover, Winifred Trotman, Gisela Brake-Silla, Selene Nunez-Cruz, Gerald Wertheim, Hyun-Jeong Ra, Elizabeth Griffiths, Charalampos Papachristou, Gwenn Danet-Desnoyers, Martin Carroll   +15 more
doaj   +1 more source

Exploring downstream pathways of aberrantly activated kinases for targeted leukemia therapy [PDF]

, 2008
Genetic alterations resulting in uncontrolled protein tyrosine kinases (PTKs) activity are frequently found in leukemia and in human solid cancers. Although the development of small molecule kinase inhibitors has revolutionized therapy for PTKinduced ...
Gasser, Christelle
core   +1 more source

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

Haematologica, 2008
Background Aurora kinases play an essential role in the orchestration of chromosome separation and cytokinesis during mitosis. Small-molecule inhibition of the aurora kinases has been shown to result in inhibition of cell division, phosphorylation of ...
Elisabeth Walsby, Val Walsh, Chris Pepper, Alan Burnett, Ken Mills   +4 more
doaj   +1 more source