Results 151 to 160 of about 346,103 (330)
Advanced Science, EarlyView.Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang +10 more
wiley +1 more source
Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022 Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem +6 more
wiley +1 more source
Haematologica, 2019 Normal hematopoiesis can be disrupted by the leukemic bone marrow microenvironment, which leads to cytopenia-associated symptoms including anemia, hemorrhage and infection.
Ai Gao +10 more
doaj +1 more source
A mathematical model of clonal hematopoiesis explaining phase transitions in myeloid leukemia [PDF]
arXivThis study presents a mathematical model describing cloned hematopoiesis in chronic myeloid leukemia (CML) through a nonlinear system of differential equations. The primary objective is to understand the progression from normal hematopoiesis to the chronic and accelerated-acute phases in myeloid leukemia.
arxiv
Metabolic gatekeeper function of B-lymphoid transcription factors. [PDF]
, 2017 B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development, yet lesions of the genes encoding these transcription factors occur in over 80% of cases of pre-B-cell acute lymphoblastic leukaemia (ALL).
Borkhardt, Arndt +26 more
core
MRAS: Master Regulator Analysis of Alternative Splicing
Advanced Science, EarlyView.This study developed a computational approach called MRAS, designed to identify master regulators of splicing differences across various biological contexts. In this framework, altered RBP expression, rather than spliceosomal mutations or other modifications, plays a central role in driving these splicing differences.
Lei Zhou +9 more
wiley +1 more source
Cancer Communications, Volume 42, Issue 12, Page 1387-1402, December 2022., 2022 Abstract Background Patients with refractory or relapsed acute myeloid leukemia (AML) have poor survival, necessitating the exploration of optimized therapeutic strategy. Here, we aimed to investigate clinical outcomes and health‐related quality of life (HR‐QoL) after total therapy, which included allogeneic hematopoietic stem cell transplantation ...
Chen‐hua Yan +13 more
wiley +1 more source
The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia
Haematologica, 2018 Epigenetic alterations contribute to leukemogenesis in childhood acute myeloid leukemia and therefore are of interest for potential therapeutic strategies.
Yaser Heshmati +11 more
doaj +1 more source
Advanced Science, EarlyView.When the normal kidney is subjected to injurious stimuli, it can lead to persistent activation of ATG5. The activation of ATG5 promotes HSP90‐HIF‐1α interaction, resulting in stabilization of HIF‐1α and subsequent activation of glycolysis. Consequently, this process contributes to mitochondrial fission and inflammation, ultimately culminating in kidney
Yan Hu +11 more
wiley +1 more source
Tumor Biology, 2019 Aurora kinases play critical roles in regulating several processes pivotal for mitosis. Radotinib, which is approved in South Korea as a second-line treatment for chronic myeloid leukemia, inhibits the tyrosine kinase BCR-ABL and platelet-derived growth ...
Sook-Kyoung Heo +10 more
doaj +1 more source